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Fusion gene ID: 25357

FusionGeneSummary for OCIAD1_SH3GLB2

Fusion gene summary

Fusion gene information	Fusion gene name: OCIAD1_SH3GLB2
	Fusion gene ID: 25357
		Hgene	Tgene
	Gene symbol	OCIAD1	SH3GLB2
	Gene ID	54940	56904
	Gene name	OCIA domain containing 1	SH3 domain containing GRB2 like, endophilin B2
	Synonyms	ASRIJ\|OCIA\|TPA018	PP6569\|PP9455\|RRIG1
	Cytomap	4p11	9q34.11
	Type of gene	protein-coding	protein-coding
	Description	OCIA domain-containing protein 1ovarian cancer immunoreactive antigen domain containing 1ovarian cancer immunoreactive antigen domain containing 1Aovarian carcinoma immunoreactive antigen	endophilin-B2SH3 domain-containing GRB2-like protein B2SH3-containing protein SH3GLB2SH3-domain GRB2-like endophilin B2retinoid receptor-induced gene 1
	Modification date	20180519	20180522
	UniProtAcc	Q9NX40	Q9NR46
	Ensembl transtripts involved in fusion gene	ENST00000509122, ENST00000512981, ENST00000396448, ENST00000264312, ENST00000381473, ENST00000444354, ENST00000506801, ENST00000425583, ENST00000508293, ENST00000513391,	ENST00000372564, ENST00000372559, ENST00000372554, ENST00000417224, ENST00000416629,
Fusion gene scores	* DoF score	5 X 5 X 3=75	1 X 1 X 1=1
	# samples	5	1
	** MAII score	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: OCIAD1 [Title/Abstract] AND SH3GLB2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AI018597	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000509122	ENST00000372564	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000509122	ENST00000372559	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000509122	ENST00000372554	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000509122	ENST00000417224	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000509122	ENST00000416629	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000512981	ENST00000372564	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000512981	ENST00000372559	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000512981	ENST00000372554	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000512981	ENST00000417224	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000512981	ENST00000416629	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000396448	ENST00000372564	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000396448	ENST00000372559	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000396448	ENST00000372554	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000396448	ENST00000417224	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000396448	ENST00000416629	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000264312	ENST00000372564	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000264312	ENST00000372559	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000264312	ENST00000372554	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000264312	ENST00000417224	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000264312	ENST00000416629	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000381473	ENST00000372564	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000381473	ENST00000372559	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000381473	ENST00000372554	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000381473	ENST00000417224	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000381473	ENST00000416629	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000444354	ENST00000372564	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000444354	ENST00000372559	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000444354	ENST00000372554	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000444354	ENST00000417224	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000444354	ENST00000416629	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000506801	ENST00000372564	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000506801	ENST00000372559	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000506801	ENST00000372554	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000506801	ENST00000417224	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000506801	ENST00000416629	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000425583	ENST00000372564	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000425583	ENST00000372559	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000425583	ENST00000372554	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000425583	ENST00000417224	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000425583	ENST00000416629	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000508293	ENST00000372564	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000508293	ENST00000372559	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000508293	ENST00000372554	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000508293	ENST00000417224	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000508293	ENST00000416629	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000513391	ENST00000372564	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000513391	ENST00000372559	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000513391	ENST00000372554	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000513391	ENST00000417224	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+
intron-intron	ENST00000513391	ENST00000416629	OCIAD1	chr4	48862220	+	SH3GLB2	chr9	131783369	+

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FusionProtFeatures for OCIAD1_SH3GLB2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
OCIAD1 Q9NX40	SH3GLB2 Q9NR46

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Fusion gene ID: 25357

FusionGeneSummary for OCIAD1_SH3GLB2

FusionProtFeatures for OCIAD1_SH3GLB2