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Fusion gene ID: 25323 |
FusionGeneSummary for OASL_NUPL2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: OASL_NUPL2 | Fusion gene ID: 25323 | Hgene | Tgene | Gene symbol | OASL | NUPL2 | Gene ID | 8638 | 11097 |
| Gene name | 2'-5'-oligoadenylate synthetase like | nucleoporin like 2 | |
| Synonyms | OASL1|OASLd|TRIP-14|TRIP14|p59 OASL|p59-OASL|p59OASL | CG1|NLP-1|NLP_1|hCG1 | |
| Cytomap | 12q24.31 | 7p15.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 2'-5'-oligoadenylate synthase-like protein2'-5'-OAS-RP2'-5'-OAS-related protein59 kDa 2'-5'-oligoadenylate synthase-like protein59 kDa 2'-5'-oligoadenylate synthetase-like proteinTR-interacting protein 14thyroid receptor-interacting protein 14 | nucleoporin-like protein 2H_RG271G13.9NUP42 homolognucleoporin hCG1nucleoporin-like protein 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q15646 | O15504 | |
| Ensembl transtripts involved in fusion gene | ENST00000257570, ENST00000339275, | ENST00000258742, ENST00000410002, ENST00000487595, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 2 X 2=12 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: OASL [Title/Abstract] AND NUPL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | OASL | GO:0009615 | response to virus | 18931074|20074559 |
| Hgene | OASL | GO:0045071 | negative regulation of viral genome replication | 18931074|20074559 |
| Hgene | OASL | GO:0051607 | defense response to virus | 21478870 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-A3LT-01A | OASL | chr12 | 121476577 | - | NUPL2 | chr7 | 23239077 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000257570 | ENST00000258742 | OASL | chr12 | 121476577 | - | NUPL2 | chr7 | 23239077 | + |
| 5CDS-intron | ENST00000257570 | ENST00000410002 | OASL | chr12 | 121476577 | - | NUPL2 | chr7 | 23239077 | + |
| 5CDS-intron | ENST00000257570 | ENST00000487595 | OASL | chr12 | 121476577 | - | NUPL2 | chr7 | 23239077 | + |
| In-frame | ENST00000339275 | ENST00000258742 | OASL | chr12 | 121476577 | - | NUPL2 | chr7 | 23239077 | + |
| 5CDS-intron | ENST00000339275 | ENST00000410002 | OASL | chr12 | 121476577 | - | NUPL2 | chr7 | 23239077 | + |
| 5CDS-intron | ENST00000339275 | ENST00000487595 | OASL | chr12 | 121476577 | - | NUPL2 | chr7 | 23239077 | + |
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FusionProtFeatures for OASL_NUPL2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| OASL | NUPL2 |