|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 25318 |
FusionGeneSummary for OAS1_RPH3A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: OAS1_RPH3A | Fusion gene ID: 25318 | Hgene | Tgene | Gene symbol | OAS1 | RPH3A | Gene ID | 4938 | 22895 |
| Gene name | 2'-5'-oligoadenylate synthetase 1 | rabphilin 3A | |
| Synonyms | E18/E16|IFI-4|OIAS|OIASI | - | |
| Cytomap | 12q24.13 | 12q24.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 2'-5'-oligoadenylate synthase 1(2-5')oligo(A) synthase 12',5'-oligo A synthetase 12'-5'-oligoadenylate synthetase 1, 40/46kDa2'-5'-oligoisoadenylate synthetase 12-5A synthase 12-5A synthetase 1E16 (2'-5') oligo A synthetase | rabphilin-3Aexophilin-1rabphilin 3A homolog | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P00973 | Q9Y2J0 | |
| Ensembl transtripts involved in fusion gene | ENST00000202917, ENST00000445409, ENST00000452357, ENST00000551241, ENST00000553185, | ENST00000543106, ENST00000389385, ENST00000447659, ENST00000551052, ENST00000415485, ENST00000548866, ENST00000420983, ENST00000549913, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 5 X 5 X 5=125 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: OAS1 [Title/Abstract] AND RPH3A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | OAS1 | GO:0009615 | response to virus | 18931074 |
| Hgene | OAS1 | GO:0045071 | negative regulation of viral genome replication | 18931074 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | CESC | TCGA-VS-A9UB-01A | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000202917 | ENST00000543106 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000202917 | ENST00000389385 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000202917 | ENST00000447659 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000202917 | ENST00000551052 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000202917 | ENST00000415485 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000202917 | ENST00000548866 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000202917 | ENST00000420983 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| 5CDS-3UTR | ENST00000202917 | ENST00000549913 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000445409 | ENST00000543106 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000445409 | ENST00000389385 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000445409 | ENST00000447659 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000445409 | ENST00000551052 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000445409 | ENST00000415485 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000445409 | ENST00000548866 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000445409 | ENST00000420983 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| 5CDS-3UTR | ENST00000445409 | ENST00000549913 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000452357 | ENST00000543106 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000452357 | ENST00000389385 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000452357 | ENST00000447659 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000452357 | ENST00000551052 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000452357 | ENST00000415485 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000452357 | ENST00000548866 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000452357 | ENST00000420983 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| 5CDS-3UTR | ENST00000452357 | ENST00000549913 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000551241 | ENST00000543106 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000551241 | ENST00000389385 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000551241 | ENST00000447659 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000551241 | ENST00000551052 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000551241 | ENST00000415485 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000551241 | ENST00000548866 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| Frame-shift | ENST00000551241 | ENST00000420983 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| 5CDS-3UTR | ENST00000551241 | ENST00000549913 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| intron-3CDS | ENST00000553185 | ENST00000543106 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| intron-3CDS | ENST00000553185 | ENST00000389385 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| intron-3CDS | ENST00000553185 | ENST00000447659 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| intron-3CDS | ENST00000553185 | ENST00000551052 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| intron-3CDS | ENST00000553185 | ENST00000415485 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| intron-3CDS | ENST00000553185 | ENST00000548866 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| intron-3CDS | ENST00000553185 | ENST00000420983 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
| intron-3UTR | ENST00000553185 | ENST00000549913 | OAS1 | chr12 | 113349040 | + | RPH3A | chr12 | 113307564 | + |
Top |
FusionProtFeatures for OAS1_RPH3A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| OAS1 | RPH3A |