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Fusion gene ID: 25269 |
FusionGeneSummary for NUPL1_KL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NUPL1_KL | Fusion gene ID: 25269 | Hgene | Tgene | Gene symbol | NUPL1 | KL | Gene ID | 9818 | 9365 |
| Gene name | nucleoporin 58 | klotho | |
| Synonyms | NUP45|NUPL1|PRO2463 | - | |
| Cytomap | 13q12.13 | 13q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nucleoporin p58/p4558 kDa nucleoporinnucleoporin 58kDanucleoporin like 1nucleoporin-like protein 1 | klotho | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UEF7 | ||
| Ensembl transtripts involved in fusion gene | ENST00000381736, ENST00000463407, ENST00000466694, ENST00000381718, | ENST00000426690, ENST00000487852, ENST00000380099, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: NUPL1 [Title/Abstract] AND KL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-EE-A29C-06A | NUPL1 | chr13 | 25876018 | + | KL | chr13 | 33627904 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000381736 | ENST00000426690 | NUPL1 | chr13 | 25876018 | + | KL | chr13 | 33627904 | + |
| 5CDS-3UTR | ENST00000381736 | ENST00000487852 | NUPL1 | chr13 | 25876018 | + | KL | chr13 | 33627904 | + |
| 5CDS-3UTR | ENST00000381736 | ENST00000380099 | NUPL1 | chr13 | 25876018 | + | KL | chr13 | 33627904 | + |
| 5CDS-5UTR | ENST00000463407 | ENST00000426690 | NUPL1 | chr13 | 25876018 | + | KL | chr13 | 33627904 | + |
| 5CDS-3UTR | ENST00000463407 | ENST00000487852 | NUPL1 | chr13 | 25876018 | + | KL | chr13 | 33627904 | + |
| 5CDS-3UTR | ENST00000463407 | ENST00000380099 | NUPL1 | chr13 | 25876018 | + | KL | chr13 | 33627904 | + |
| 3UTR-5UTR | ENST00000466694 | ENST00000426690 | NUPL1 | chr13 | 25876018 | + | KL | chr13 | 33627904 | + |
| 3UTR-3UTR | ENST00000466694 | ENST00000487852 | NUPL1 | chr13 | 25876018 | + | KL | chr13 | 33627904 | + |
| 3UTR-3UTR | ENST00000466694 | ENST00000380099 | NUPL1 | chr13 | 25876018 | + | KL | chr13 | 33627904 | + |
| 5CDS-5UTR | ENST00000381718 | ENST00000426690 | NUPL1 | chr13 | 25876018 | + | KL | chr13 | 33627904 | + |
| 5CDS-3UTR | ENST00000381718 | ENST00000487852 | NUPL1 | chr13 | 25876018 | + | KL | chr13 | 33627904 | + |
| 5CDS-3UTR | ENST00000381718 | ENST00000380099 | NUPL1 | chr13 | 25876018 | + | KL | chr13 | 33627904 | + |
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FusionProtFeatures for NUPL1_KL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUPL1 | KL |