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Fusion gene ID: 25245

FusionGeneSummary for NUP85_NR5A2

Fusion gene summary

Fusion gene information	Fusion gene name: NUP85_NR5A2
	Fusion gene ID: 25245
		Hgene	Tgene
	Gene symbol	NUP85	NR5A2
	Gene ID	79902	2494
	Gene name	nucleoporin 85	nuclear receptor subfamily 5 group A member 2
	Synonyms	FROUNT\|Nup75	B1F\|B1F2\|CPF\|FTF\|FTZ-F1\|FTZ-F1beta\|LRH-1\|LRH1\|hB1F-2
	Cytomap	17q25.1	1q32.1
	Type of gene	protein-coding	protein-coding
	Description	nuclear pore complex protein Nup85nucleoporin 85kDanucleoporin Nup75nucleoporin Nup85	nuclear receptor subfamily 5 group A member 2CYP7A promoter-binding factorb1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virusfetoprotein-alpha 1 (AFP) transcription factorhepatocytic transcription factor
	Modification date	20180523	20180527
	UniProtAcc	Q9BW27	O00482
	Ensembl transtripts involved in fusion gene	ENST00000245544, ENST00000541827, ENST00000579324, ENST00000449421, ENST00000579298, ENST00000447371, ENST00000540768,	ENST00000367362, ENST00000236914, ENST00000544748,
Fusion gene scores	* DoF score	5 X 6 X 4=120	2 X 1 X 2=4
	# samples	7	2
	** MAII score	log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/4*10)=2.32192809488736
Context	PubMed: NUP85 [Title/Abstract] AND NR5A2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NR5A2	GO:0006355	regulation of transcription, DNA-templated	15723037
Tgene	NR5A2	GO:0045070	positive regulation of viral genome replication	19264593
Tgene	NR5A2	GO:0045893	positive regulation of transcription, DNA-templated	15143342

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LUSC	TCGA-NK-A5D1-01A	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000245544	ENST00000367362	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
In-frame	ENST00000245544	ENST00000236914	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
In-frame	ENST00000245544	ENST00000544748	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
5UTR-3CDS	ENST00000541827	ENST00000367362	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
5UTR-3CDS	ENST00000541827	ENST00000236914	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
5UTR-3CDS	ENST00000541827	ENST00000544748	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
5UTR-3CDS	ENST00000579324	ENST00000367362	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
5UTR-3CDS	ENST00000579324	ENST00000236914	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
5UTR-3CDS	ENST00000579324	ENST00000544748	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
3UTR-3CDS	ENST00000449421	ENST00000367362	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
3UTR-3CDS	ENST00000449421	ENST00000236914	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
3UTR-3CDS	ENST00000449421	ENST00000544748	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
In-frame	ENST00000579298	ENST00000367362	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
In-frame	ENST00000579298	ENST00000236914	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
In-frame	ENST00000579298	ENST00000544748	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
5UTR-3CDS	ENST00000447371	ENST00000367362	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
5UTR-3CDS	ENST00000447371	ENST00000236914	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
5UTR-3CDS	ENST00000447371	ENST00000544748	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
intron-3CDS	ENST00000540768	ENST00000367362	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
intron-3CDS	ENST00000540768	ENST00000236914	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+
intron-3CDS	ENST00000540768	ENST00000544748	NUP85	chr17	73201889	+	NR5A2	chr1	200080330	+

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FusionProtFeatures for NUP85_NR5A2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NUP85 Q9BW27	NR5A2 O00482

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Fusion gene ID: 25245

FusionGeneSummary for NUP85_NR5A2

FusionProtFeatures for NUP85_NR5A2