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Fusion gene ID: 25236 |
FusionGeneSummary for NUP54_CXCL9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NUP54_CXCL9 | Fusion gene ID: 25236 | Hgene | Tgene | Gene symbol | NUP54 | CXCL9 | Gene ID | 53371 | 4283 |
| Gene name | nucleoporin 54 | C-X-C motif chemokine ligand 9 | |
| Synonyms | - | CMK|Humig|MIG|SCYB9|crg-10 | |
| Cytomap | 4q21.1 | 4q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nucleoporin p5454 kDa nucleoporinnucleoporin 54kDnucleoporin 54kDa | C-X-C motif chemokine 9chemokine (C-X-C motif) ligand 9gamma-interferon-induced monokinemonokine induced by gamma interferonmonokine induced by interferon-gammasmall-inducible cytokine B9 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q7Z3B4 | Q07325 | |
| Ensembl transtripts involved in fusion gene | ENST00000264883, ENST00000342467, ENST00000514987, ENST00000458189, ENST00000515460, | ENST00000264888, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 2 X 3=18 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NUP54 [Title/Abstract] AND CXCL9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CXCL9 | GO:0006935 | chemotaxis | 12782716 |
| Tgene | CXCL9 | GO:0030816 | positive regulation of cAMP metabolic process | 12782716 |
| Tgene | CXCL9 | GO:0042127 | regulation of cell proliferation | 12782716 |
| Tgene | CXCL9 | GO:0043950 | positive regulation of cAMP-mediated signaling | 12782716 |
| Tgene | CXCL9 | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 12782716 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-69-8255-01A | NUP54 | chr4 | 77045802 | - | CXCL9 | chr4 | 76927427 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000264883 | ENST00000264888 | NUP54 | chr4 | 77045802 | - | CXCL9 | chr4 | 76927427 | - |
| intron-3CDS | ENST00000342467 | ENST00000264888 | NUP54 | chr4 | 77045802 | - | CXCL9 | chr4 | 76927427 | - |
| Frame-shift | ENST00000514987 | ENST00000264888 | NUP54 | chr4 | 77045802 | - | CXCL9 | chr4 | 76927427 | - |
| Frame-shift | ENST00000458189 | ENST00000264888 | NUP54 | chr4 | 77045802 | - | CXCL9 | chr4 | 76927427 | - |
| intron-3CDS | ENST00000515460 | ENST00000264888 | NUP54 | chr4 | 77045802 | - | CXCL9 | chr4 | 76927427 | - |
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FusionProtFeatures for NUP54_CXCL9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUP54 | CXCL9 |