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Fusion gene ID: 25183 |
FusionGeneSummary for NUP153_DTNBP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NUP153_DTNBP1 | Fusion gene ID: 25183 | Hgene | Tgene | Gene symbol | NUP153 | DTNBP1 | Gene ID | 9972 | 84062 |
| Gene name | nucleoporin 153 | dystrobrevin binding protein 1 | |
| Synonyms | HNUP153|N153 | BLOC1S8|DBND|HPS7|My031|SDY | |
| Cytomap | 6p22.3 | 6p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear pore complex protein Nup153153 kDa nucleoporinnuclear pore complex protein hnup153nucleoporin 153kDnucleoporin 153kDanucleoporin Nup153 | dysbindinBLOC-1 subunit 8Hermansky-Pudlak syndrome 7 proteinbiogenesis of lysosomal organelles complex-1, subunit 8biogenesis of lysosome-related organelles complex 1 subunit 8dysbindin-1 | |
| Modification date | 20180527 | 20180522 | |
| UniProtAcc | P49790 | Q96EV8 | |
| Ensembl transtripts involved in fusion gene | ENST00000262077, ENST00000537253, | ENST00000344537, ENST00000355917, ENST00000338950, ENST00000462989, | |
| Fusion gene scores | * DoF score | 10 X 7 X 8=560 | 9 X 5 X 7=315 |
| # samples | 11 | 9 | |
| ** MAII score | log2(11/560*10)=-2.34792330342031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/315*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NUP153 [Title/Abstract] AND DTNBP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NUP153 | GO:0046832 | negative regulation of RNA export from nucleus | 22253824 |
| Tgene | DTNBP1 | GO:0031175 | neuron projection development | 16980328 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-PQ-A6FI-01A | NUP153 | chr6 | 17646298 | - | DTNBP1 | chr6 | 15524900 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000262077 | ENST00000344537 | NUP153 | chr6 | 17646298 | - | DTNBP1 | chr6 | 15524900 | - |
| In-frame | ENST00000262077 | ENST00000355917 | NUP153 | chr6 | 17646298 | - | DTNBP1 | chr6 | 15524900 | - |
| In-frame | ENST00000262077 | ENST00000338950 | NUP153 | chr6 | 17646298 | - | DTNBP1 | chr6 | 15524900 | - |
| In-frame | ENST00000262077 | ENST00000462989 | NUP153 | chr6 | 17646298 | - | DTNBP1 | chr6 | 15524900 | - |
| In-frame | ENST00000537253 | ENST00000344537 | NUP153 | chr6 | 17646298 | - | DTNBP1 | chr6 | 15524900 | - |
| In-frame | ENST00000537253 | ENST00000355917 | NUP153 | chr6 | 17646298 | - | DTNBP1 | chr6 | 15524900 | - |
| In-frame | ENST00000537253 | ENST00000338950 | NUP153 | chr6 | 17646298 | - | DTNBP1 | chr6 | 15524900 | - |
| In-frame | ENST00000537253 | ENST00000462989 | NUP153 | chr6 | 17646298 | - | DTNBP1 | chr6 | 15524900 | - |
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FusionProtFeatures for NUP153_DTNBP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUP153 | DTNBP1 |