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Fusion gene ID: 2516 |
FusionGeneSummary for ARHGEF12_C14orf2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGEF12_C14orf2 | Fusion gene ID: 2516 | Hgene | Tgene | Gene symbol | ARHGEF12 | C14orf2 | Gene ID | 23365 |
| Gene name | Rho guanine nucleotide exchange factor 12 | ||
| Synonyms | LARG|PRO2792 | ||
| Cytomap | 11q23.3 | ||
| Type of gene | protein-coding | ||
| Description | rho guanine nucleotide exchange factor 12Rho guanine nucleotide exchange factor (GEF) 12leukemia-associated RhoGEFleukemia-associated rho guanine nucleotide exchange factor | ||
| Modification date | 20180519 | ||
| UniProtAcc | Q9NZN5 | ||
| Ensembl transtripts involved in fusion gene | ENST00000397843, ENST00000356641, ENST00000532993, | ENST00000286953, ENST00000554880, ENST00000555030, ENST00000414262, ENST00000553430, ENST00000557040, ENST00000553449, ENST00000554713, | |
| Fusion gene scores | * DoF score | 11 X 8 X 8=704 | 3 X 2 X 3=18 |
| # samples | 14 | 4 | |
| ** MAII score | log2(14/704*10)=-2.33014860169233 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ARHGEF12 [Title/Abstract] AND C14orf2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARHGEF12 | GO:0007186 | G-protein coupled receptor signaling pathway | 15755723 |