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Fusion gene ID: 25146 |
FusionGeneSummary for NUMA1_IQSEC3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NUMA1_IQSEC3 | Fusion gene ID: 25146 | Hgene | Tgene | Gene symbol | NUMA1 | IQSEC3 | Gene ID | 4926 | 440073 |
| Gene name | nuclear mitotic apparatus protein 1 | IQ motif and Sec7 domain 3 | |
| Synonyms | NMP-22|NUMA | - | |
| Cytomap | 11q13.4 | 12p13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear mitotic apparatus protein 1SP-H antigencentrophilin stabilizes mitotic spindle in mitotic cellsnuclear matrix protein-22structural nuclear protein | IQ motif and SEC7 domain-containing protein 3 | |
| Modification date | 20180523 | 20180403 | |
| UniProtAcc | Q14980 | Q9UPP2 | |
| Ensembl transtripts involved in fusion gene | ENST00000351960, ENST00000358965, ENST00000393695, ENST00000543450, | ENST00000538872, ENST00000326261, ENST00000382841, ENST00000537151, | |
| Fusion gene scores | * DoF score | 29 X 14 X 14=5684 | 4 X 4 X 4=64 |
| # samples | 31 | 4 | |
| ** MAII score | log2(31/5684*10)=-4.19656643396854 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NUMA1 [Title/Abstract] AND IQSEC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NUMA1 | GO:0000132 | establishment of mitotic spindle orientation | 21816348 |
| Hgene | NUMA1 | GO:0030953 | astral microtubule organization | 12445386 |
| Hgene | NUMA1 | GO:0060236 | regulation of mitotic spindle organization | 26195665 |
| Hgene | NUMA1 | GO:1902365 | positive regulation of protein localization to spindle pole body | 16076287 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-IG-A8O2-01A | NUMA1 | chr11 | 71780888 | - | IQSEC3 | chr12 | 208312 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000351960 | ENST00000538872 | NUMA1 | chr11 | 71780888 | - | IQSEC3 | chr12 | 208312 | + |
| 5UTR-3CDS | ENST00000351960 | ENST00000326261 | NUMA1 | chr11 | 71780888 | - | IQSEC3 | chr12 | 208312 | + |
| 5UTR-5UTR | ENST00000351960 | ENST00000382841 | NUMA1 | chr11 | 71780888 | - | IQSEC3 | chr12 | 208312 | + |
| 5UTR-intron | ENST00000351960 | ENST00000537151 | NUMA1 | chr11 | 71780888 | - | IQSEC3 | chr12 | 208312 | + |
| 5UTR-3CDS | ENST00000358965 | ENST00000538872 | NUMA1 | chr11 | 71780888 | - | IQSEC3 | chr12 | 208312 | + |
| 5UTR-3CDS | ENST00000358965 | ENST00000326261 | NUMA1 | chr11 | 71780888 | - | IQSEC3 | chr12 | 208312 | + |
| 5UTR-5UTR | ENST00000358965 | ENST00000382841 | NUMA1 | chr11 | 71780888 | - | IQSEC3 | chr12 | 208312 | + |
| 5UTR-intron | ENST00000358965 | ENST00000537151 | NUMA1 | chr11 | 71780888 | - | IQSEC3 | chr12 | 208312 | + |
| 5UTR-3CDS | ENST00000393695 | ENST00000538872 | NUMA1 | chr11 | 71780888 | - | IQSEC3 | chr12 | 208312 | + |
| 5UTR-3CDS | ENST00000393695 | ENST00000326261 | NUMA1 | chr11 | 71780888 | - | IQSEC3 | chr12 | 208312 | + |
| 5UTR-5UTR | ENST00000393695 | ENST00000382841 | NUMA1 | chr11 | 71780888 | - | IQSEC3 | chr12 | 208312 | + |
| 5UTR-intron | ENST00000393695 | ENST00000537151 | NUMA1 | chr11 | 71780888 | - | IQSEC3 | chr12 | 208312 | + |
| 5UTR-3CDS | ENST00000543450 | ENST00000538872 | NUMA1 | chr11 | 71780888 | - | IQSEC3 | chr12 | 208312 | + |
| 5UTR-3CDS | ENST00000543450 | ENST00000326261 | NUMA1 | chr11 | 71780888 | - | IQSEC3 | chr12 | 208312 | + |
| 5UTR-5UTR | ENST00000543450 | ENST00000382841 | NUMA1 | chr11 | 71780888 | - | IQSEC3 | chr12 | 208312 | + |
| 5UTR-intron | ENST00000543450 | ENST00000537151 | NUMA1 | chr11 | 71780888 | - | IQSEC3 | chr12 | 208312 | + |
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FusionProtFeatures for NUMA1_IQSEC3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUMA1 | IQSEC3 |