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Fusion gene ID: 25113 |
FusionGeneSummary for NUDT3_SERINC5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NUDT3_SERINC5 | Fusion gene ID: 25113 | Hgene | Tgene | Gene symbol | NUDT3 | SERINC5 | Gene ID | 11165 | 256987 |
| Gene name | nudix hydrolase 3 | serine incorporator 5 | |
| Synonyms | DIPP|DIPP-1|DIPP1 | C5orf12|TPO1 | |
| Cytomap | 6p21.31 | 5q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | diphosphoinositol polyphosphate phosphohydrolase 1diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1nucleoside diphosphate-linked moiety X motif 3nudix (nucleoside diphosphate linked moiety X)-type motif 3nudix motif 3 | serine incorporator 5 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O95989 | Q86VE9 | |
| Ensembl transtripts involved in fusion gene | ENST00000607016, | ENST00000507668, ENST00000512972, ENST00000509193, ENST00000512721, ENST00000513907, | |
| Fusion gene scores | * DoF score | 13 X 9 X 7=819 | 5 X 5 X 4=100 |
| # samples | 16 | 6 | |
| ** MAII score | log2(16/819*10)=-2.35579154675365 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NUDT3 [Title/Abstract] AND SERINC5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NUDT3 | GO:0071544 | diphosphoinositol polyphosphate catabolic process | 10585413 |
| Tgene | SERINC5 | GO:0009597 | detection of virus | 26416733|26416734 |
| Tgene | SERINC5 | GO:0045087 | innate immune response | 26416733|26416734 |
| Tgene | SERINC5 | GO:0051607 | defense response to virus | 26416733|26416734 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW954850 | NUDT3 | chr6 | 34256662 | - | SERINC5 | chr5 | 79435910 | - | ||
| ChiTaRS3.1 | AA314460 | NUDT3 | chr6 | 34256662 | - | SERINC5 | chr5 | 79435910 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000607016 | ENST00000507668 | NUDT3 | chr6 | 34256662 | - | SERINC5 | chr5 | 79435910 | - |
| intron-intron | ENST00000607016 | ENST00000512972 | NUDT3 | chr6 | 34256662 | - | SERINC5 | chr5 | 79435910 | - |
| intron-intron | ENST00000607016 | ENST00000509193 | NUDT3 | chr6 | 34256662 | - | SERINC5 | chr5 | 79435910 | - |
| intron-intron | ENST00000607016 | ENST00000512721 | NUDT3 | chr6 | 34256662 | - | SERINC5 | chr5 | 79435910 | - |
| intron-intron | ENST00000607016 | ENST00000513907 | NUDT3 | chr6 | 34256662 | - | SERINC5 | chr5 | 79435910 | - |
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FusionProtFeatures for NUDT3_SERINC5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUDT3 | SERINC5 |