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Fusion gene ID: 25084 |
FusionGeneSummary for NUDT16L1_FAHD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NUDT16L1_FAHD1 | Fusion gene ID: 25084 | Hgene | Tgene | Gene symbol | NUDT16L1 | FAHD1 | Gene ID | 84309 | 81889 |
| Gene name | nudix hydrolase 16 like 1 | fumarylacetoacetate hydrolase domain containing 1 | |
| Synonyms | SDOS | C16orf36|YISKL | |
| Cytomap | 16p13.3 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tudor-interacting repair regulator proteinNUDT16-like protein 1TIRRnudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1protein syndesmossyndesmos | acylpyruvase FAHD1, mitochondrialFAH domain-containing protein 1OAA decarboxylaseYISK like/RJD15acylpyruvate hydrolasefumarylacetoacetate hydrolase domain-containing protein 1oxaloacetate decarboxylaseyisK-like protein | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9BRJ7 | Q6P587 | |
| Ensembl transtripts involved in fusion gene | ENST00000304301, ENST00000586252, ENST00000586536, ENST00000405142, | ENST00000382668, ENST00000382666, ENST00000427358, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 2 X 3=18 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NUDT16L1 [Title/Abstract] AND FAHD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NUDT16L1 | GO:2001033 | negative regulation of double-strand break repair via nonhomologous end joining | 28241136 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-06-5856-01A | NUDT16L1 | chr16 | 4744239 | + | FAHD1 | chr16 | 1888017 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000304301 | ENST00000382668 | NUDT16L1 | chr16 | 4744239 | + | FAHD1 | chr16 | 1888017 | + |
| 5CDS-intron | ENST00000304301 | ENST00000382666 | NUDT16L1 | chr16 | 4744239 | + | FAHD1 | chr16 | 1888017 | + |
| 5CDS-intron | ENST00000304301 | ENST00000427358 | NUDT16L1 | chr16 | 4744239 | + | FAHD1 | chr16 | 1888017 | + |
| 5CDS-intron | ENST00000586252 | ENST00000382668 | NUDT16L1 | chr16 | 4744239 | + | FAHD1 | chr16 | 1888017 | + |
| 5CDS-intron | ENST00000586252 | ENST00000382666 | NUDT16L1 | chr16 | 4744239 | + | FAHD1 | chr16 | 1888017 | + |
| 5CDS-intron | ENST00000586252 | ENST00000427358 | NUDT16L1 | chr16 | 4744239 | + | FAHD1 | chr16 | 1888017 | + |
| 5CDS-intron | ENST00000586536 | ENST00000382668 | NUDT16L1 | chr16 | 4744239 | + | FAHD1 | chr16 | 1888017 | + |
| 5CDS-intron | ENST00000586536 | ENST00000382666 | NUDT16L1 | chr16 | 4744239 | + | FAHD1 | chr16 | 1888017 | + |
| 5CDS-intron | ENST00000586536 | ENST00000427358 | NUDT16L1 | chr16 | 4744239 | + | FAHD1 | chr16 | 1888017 | + |
| 5CDS-intron | ENST00000405142 | ENST00000382668 | NUDT16L1 | chr16 | 4744239 | + | FAHD1 | chr16 | 1888017 | + |
| 5CDS-intron | ENST00000405142 | ENST00000382666 | NUDT16L1 | chr16 | 4744239 | + | FAHD1 | chr16 | 1888017 | + |
| 5CDS-intron | ENST00000405142 | ENST00000427358 | NUDT16L1 | chr16 | 4744239 | + | FAHD1 | chr16 | 1888017 | + |
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FusionProtFeatures for NUDT16L1_FAHD1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUDT16L1 | FAHD1 |