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Fusion gene ID: 25053 |
FusionGeneSummary for NUCKS1_ASRGL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NUCKS1_ASRGL1 | Fusion gene ID: 25053 | Hgene | Tgene | Gene symbol | NUCKS1 | ASRGL1 | Gene ID | 64710 | 80150 |
| Gene name | nuclear casein kinase and cyclin dependent kinase substrate 1 | asparaginase like 1 | |
| Synonyms | JC7|NUCKS | ALP|ALP1|CRASH | |
| Cytomap | 1q32.1 | 11q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear ubiquitous casein and cyclin-dependent kinase substrate 1P1nuclear ubiquitous casein kinase and cyclin-dependent kinase substratepotential LAG1 interactor | isoaspartyl peptidase/L-asparaginaseL-asparaginaseL-asparagine amidohydrolaseasparaginase-like 1 proteinasparaginase-like protein 1beta-aspartyl-peptidaseisoaspartyl dipeptidasetestis secretory sperm-binding protein Li 242mP | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9H1E3 | Q7L266 | |
| Ensembl transtripts involved in fusion gene | ENST00000367142, ENST00000464938, | ENST00000415229, ENST00000535727, ENST00000301776, ENST00000528206, | |
| Fusion gene scores | * DoF score | 11 X 15 X 6=990 | 4 X 4 X 2=32 |
| # samples | 24 | 4 | |
| ** MAII score | log2(24/990*10)=-2.04439411935845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NUCKS1 [Title/Abstract] AND ASRGL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NUCKS1 | GO:0031297 | replication fork processing | 26323318 |
| Tgene | ASRGL1 | GO:0033345 | asparagine catabolic process via L-aspartate | 19839645 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BQ343733 | NUCKS1 | chr1 | 205687515 | - | ASRGL1 | chr11 | 62124549 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000367142 | ENST00000415229 | NUCKS1 | chr1 | 205687515 | - | ASRGL1 | chr11 | 62124549 | + |
| intron-3CDS | ENST00000367142 | ENST00000535727 | NUCKS1 | chr1 | 205687515 | - | ASRGL1 | chr11 | 62124549 | + |
| intron-3CDS | ENST00000367142 | ENST00000301776 | NUCKS1 | chr1 | 205687515 | - | ASRGL1 | chr11 | 62124549 | + |
| intron-3UTR | ENST00000367142 | ENST00000528206 | NUCKS1 | chr1 | 205687515 | - | ASRGL1 | chr11 | 62124549 | + |
| intron-3CDS | ENST00000464938 | ENST00000415229 | NUCKS1 | chr1 | 205687515 | - | ASRGL1 | chr11 | 62124549 | + |
| intron-3CDS | ENST00000464938 | ENST00000535727 | NUCKS1 | chr1 | 205687515 | - | ASRGL1 | chr11 | 62124549 | + |
| intron-3CDS | ENST00000464938 | ENST00000301776 | NUCKS1 | chr1 | 205687515 | - | ASRGL1 | chr11 | 62124549 | + |
| intron-3UTR | ENST00000464938 | ENST00000528206 | NUCKS1 | chr1 | 205687515 | - | ASRGL1 | chr11 | 62124549 | + |
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FusionProtFeatures for NUCKS1_ASRGL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUCKS1 | ASRGL1 |