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Fusion gene ID: 25052 |
FusionGeneSummary for NUCB2_PAK3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NUCB2_PAK3 | Fusion gene ID: 25052 | Hgene | Tgene | Gene symbol | NUCB2 | PAK3 | Gene ID | 4925 | 8874 |
| Gene name | nucleobindin 2 | Rho guanine nucleotide exchange factor 7 | |
| Synonyms | HEL-S-109|NEFA | BETA-PIX|COOL-1|COOL1|Nbla10314|P50|P50BP|P85|P85COOL1|P85SPR|PAK3|PIXB | |
| Cytomap | 11p15.1 | 13q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nucleobindin-2DNA-binding protein NEFAepididymis secretory protein Li 109gastric cancer antigen Zg4nesfatin 1nucleobinding 2prepronesfatin | rho guanine nucleotide exchange factor 7PAK-interacting exchange factor betaRho guanine nucleotide exchange factor (GEF) 7SH3 domain-containing proline-rich protein | |
| Modification date | 20180527 | 20180522 | |
| UniProtAcc | P80303 | O75914 | |
| Ensembl transtripts involved in fusion gene | ENST00000323688, ENST00000529010, ENST00000458064, ENST00000532240, | ENST00000425146, ENST00000446737, ENST00000372010, ENST00000519681, ENST00000372007, ENST00000518291, ENST00000484442, ENST00000262836, ENST00000360648, ENST00000417227, | |
| Fusion gene scores | * DoF score | 3 X 5 X 1=15 | 3 X 3 X 2=18 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/15*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NUCB2 [Title/Abstract] AND PAK3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PAK3 | GO:0043547 | positive regulation of GTPase activity | 21048939 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CB243708 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000323688 | ENST00000425146 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000323688 | ENST00000446737 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000323688 | ENST00000372010 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000323688 | ENST00000519681 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000323688 | ENST00000372007 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000323688 | ENST00000518291 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000323688 | ENST00000484442 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000323688 | ENST00000262836 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000323688 | ENST00000360648 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000323688 | ENST00000417227 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000529010 | ENST00000425146 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000529010 | ENST00000446737 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000529010 | ENST00000372010 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000529010 | ENST00000519681 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000529010 | ENST00000372007 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000529010 | ENST00000518291 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000529010 | ENST00000484442 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000529010 | ENST00000262836 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000529010 | ENST00000360648 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000529010 | ENST00000417227 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000458064 | ENST00000425146 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000458064 | ENST00000446737 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000458064 | ENST00000372010 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000458064 | ENST00000519681 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000458064 | ENST00000372007 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000458064 | ENST00000518291 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000458064 | ENST00000484442 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000458064 | ENST00000262836 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000458064 | ENST00000360648 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| 5CDS-intron | ENST00000458064 | ENST00000417227 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| intron-intron | ENST00000532240 | ENST00000425146 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| intron-intron | ENST00000532240 | ENST00000446737 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| intron-intron | ENST00000532240 | ENST00000372010 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| intron-intron | ENST00000532240 | ENST00000519681 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| intron-intron | ENST00000532240 | ENST00000372007 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| intron-intron | ENST00000532240 | ENST00000518291 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| intron-intron | ENST00000532240 | ENST00000484442 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| intron-intron | ENST00000532240 | ENST00000262836 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| intron-intron | ENST00000532240 | ENST00000360648 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
| intron-intron | ENST00000532240 | ENST00000417227 | NUCB2 | chr11 | 17323332 | - | PAK3 | chrX | 110411782 | - |
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FusionProtFeatures for NUCB2_PAK3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NUCB2 | PAK3 |