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Fusion gene ID: 25043

FusionGeneSummary for NUBPL_PSMA6

Fusion gene summary

Fusion gene information	Fusion gene name: NUBPL_PSMA6
	Fusion gene ID: 25043
		Hgene	Tgene
	Gene symbol	NUBPL	PSMA6
	Gene ID	80224	5687
	Gene name	nucleotide binding protein like	proteasome subunit alpha 6
	Synonyms	C14orf127\|IND1\|huInd1	IOTA\|PROS27\|p27K
	Cytomap	14q12	14q13.2
	Type of gene	protein-coding	protein-coding
	Description	iron-sulfur protein NUBPLIND1 homologiron-sulfur protein required for NADH dehydrogenase	proteasome subunit alpha type-627 kDa prosomal proteinPROS-27macropain iota chainmacropain subunit iotamulticatalytic endopeptidase complex iota chainprosomal P27K proteinproteasome (prosome, macropain) subunit, alpha type, 6proteasome iota chain
	Modification date	20180523	20180523
	UniProtAcc	Q8TB37	P60900
	Ensembl transtripts involved in fusion gene	ENST00000281081, ENST00000536705, ENST00000418681,	ENST00000540871, ENST00000261479, ENST00000553809, ENST00000555764, ENST00000556506,
Fusion gene scores	* DoF score	3 X 3 X 3=27	5 X 3 X 4=60
	# samples	3	5
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NUBPL [Title/Abstract] AND PSMA6 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	PAAD	TCGA-2J-AABO-01A	NUBPL	chr14	32068585	+	PSMA6	chr14	35782087	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000281081	ENST00000540871	NUBPL	chr14	32068585	+	PSMA6	chr14	35782087	+
In-frame	ENST00000281081	ENST00000261479	NUBPL	chr14	32068585	+	PSMA6	chr14	35782087	+
In-frame	ENST00000281081	ENST00000553809	NUBPL	chr14	32068585	+	PSMA6	chr14	35782087	+
In-frame	ENST00000281081	ENST00000555764	NUBPL	chr14	32068585	+	PSMA6	chr14	35782087	+
In-frame	ENST00000281081	ENST00000556506	NUBPL	chr14	32068585	+	PSMA6	chr14	35782087	+
In-frame	ENST00000536705	ENST00000540871	NUBPL	chr14	32068585	+	PSMA6	chr14	35782087	+
In-frame	ENST00000536705	ENST00000261479	NUBPL	chr14	32068585	+	PSMA6	chr14	35782087	+
In-frame	ENST00000536705	ENST00000553809	NUBPL	chr14	32068585	+	PSMA6	chr14	35782087	+
In-frame	ENST00000536705	ENST00000555764	NUBPL	chr14	32068585	+	PSMA6	chr14	35782087	+
In-frame	ENST00000536705	ENST00000556506	NUBPL	chr14	32068585	+	PSMA6	chr14	35782087	+
intron-3CDS	ENST00000418681	ENST00000540871	NUBPL	chr14	32068585	+	PSMA6	chr14	35782087	+
intron-3CDS	ENST00000418681	ENST00000261479	NUBPL	chr14	32068585	+	PSMA6	chr14	35782087	+
intron-3CDS	ENST00000418681	ENST00000553809	NUBPL	chr14	32068585	+	PSMA6	chr14	35782087	+
intron-3CDS	ENST00000418681	ENST00000555764	NUBPL	chr14	32068585	+	PSMA6	chr14	35782087	+
intron-3CDS	ENST00000418681	ENST00000556506	NUBPL	chr14	32068585	+	PSMA6	chr14	35782087	+

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FusionProtFeatures for NUBPL_PSMA6

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NUBPL Q8TB37	PSMA6 P60900

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Fusion gene ID: 25043

FusionGeneSummary for NUBPL_PSMA6

FusionProtFeatures for NUBPL_PSMA6