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Fusion gene ID: 2496 |
FusionGeneSummary for ARHGEF10L_LGALS4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGEF10L_LGALS4 | Fusion gene ID: 2496 | Hgene | Tgene | Gene symbol | ARHGEF10L | LGALS4 | Gene ID | 55160 | 3960 |
| Gene name | Rho guanine nucleotide exchange factor 10 like | galectin 4 | |
| Synonyms | GrinchGEF | GAL4|L36LBP | |
| Cytomap | 1p36.13 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho guanine nucleotide exchange factor 10-like proteinRho guanine nucleotide exchange factor (GEF) 10-like | galectin-4L-36 lactose-binding proteinantigen NY-CO-27gal-4lactose-binding lectin 4lectin, galactoside-binding, soluble, 4 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9HCE6 | P56470 | |
| Ensembl transtripts involved in fusion gene | ENST00000434513, ENST00000361221, ENST00000452522, ENST00000375415, ENST00000375420, ENST00000469726, ENST00000375408, ENST00000167825, | ENST00000307751, ENST00000597803, | |
| Fusion gene scores | * DoF score | 7 X 8 X 9=504 | 5 X 4 X 4=80 |
| # samples | 11 | 5 | |
| ** MAII score | log2(11/504*10)=-2.19592020997526 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ARHGEF10L [Title/Abstract] AND LGALS4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG981808 | ARHGEF10L | chr1 | 17909092 | + | LGALS4 | chr19 | 39292540 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000434513 | ENST00000307751 | ARHGEF10L | chr1 | 17909092 | + | LGALS4 | chr19 | 39292540 | - |
| intron-intron | ENST00000434513 | ENST00000597803 | ARHGEF10L | chr1 | 17909092 | + | LGALS4 | chr19 | 39292540 | - |
| intron-3CDS | ENST00000361221 | ENST00000307751 | ARHGEF10L | chr1 | 17909092 | + | LGALS4 | chr19 | 39292540 | - |
| intron-intron | ENST00000361221 | ENST00000597803 | ARHGEF10L | chr1 | 17909092 | + | LGALS4 | chr19 | 39292540 | - |
| intron-3CDS | ENST00000452522 | ENST00000307751 | ARHGEF10L | chr1 | 17909092 | + | LGALS4 | chr19 | 39292540 | - |
| intron-intron | ENST00000452522 | ENST00000597803 | ARHGEF10L | chr1 | 17909092 | + | LGALS4 | chr19 | 39292540 | - |
| intron-3CDS | ENST00000375415 | ENST00000307751 | ARHGEF10L | chr1 | 17909092 | + | LGALS4 | chr19 | 39292540 | - |
| intron-intron | ENST00000375415 | ENST00000597803 | ARHGEF10L | chr1 | 17909092 | + | LGALS4 | chr19 | 39292540 | - |
| intron-3CDS | ENST00000375420 | ENST00000307751 | ARHGEF10L | chr1 | 17909092 | + | LGALS4 | chr19 | 39292540 | - |
| intron-intron | ENST00000375420 | ENST00000597803 | ARHGEF10L | chr1 | 17909092 | + | LGALS4 | chr19 | 39292540 | - |
| intron-3CDS | ENST00000469726 | ENST00000307751 | ARHGEF10L | chr1 | 17909092 | + | LGALS4 | chr19 | 39292540 | - |
| intron-intron | ENST00000469726 | ENST00000597803 | ARHGEF10L | chr1 | 17909092 | + | LGALS4 | chr19 | 39292540 | - |
| intron-3CDS | ENST00000375408 | ENST00000307751 | ARHGEF10L | chr1 | 17909092 | + | LGALS4 | chr19 | 39292540 | - |
| intron-intron | ENST00000375408 | ENST00000597803 | ARHGEF10L | chr1 | 17909092 | + | LGALS4 | chr19 | 39292540 | - |
| intron-3CDS | ENST00000167825 | ENST00000307751 | ARHGEF10L | chr1 | 17909092 | + | LGALS4 | chr19 | 39292540 | - |
| intron-intron | ENST00000167825 | ENST00000597803 | ARHGEF10L | chr1 | 17909092 | + | LGALS4 | chr19 | 39292540 | - |
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FusionProtFeatures for ARHGEF10L_LGALS4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARHGEF10L | LGALS4 |