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Fusion gene ID: 24955 |
FusionGeneSummary for NSRP1_ANKRD13B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NSRP1_ANKRD13B | Fusion gene ID: 24955 | Hgene | Tgene | Gene symbol | NSRP1 | ANKRD13B | Gene ID | 84081 | 124930 |
| Gene name | nuclear speckle splicing regulatory protein 1 | ankyrin repeat domain 13B | |
| Synonyms | CCDC55|HSPC095|NSrp70 | - | |
| Cytomap | 17q11.2 | 17q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear speckle splicing regulatory protein 1coiled-coil domain containing 55coiled-coil domain-containing protein 55nuclear speckle-related protein 70 | ankyrin repeat domain-containing protein 13B | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q9H0G5 | Q86YJ7 | |
| Ensembl transtripts involved in fusion gene | ENST00000540900, ENST00000584423, ENST00000247026, ENST00000479218, | ENST00000394859, | |
| Fusion gene scores | * DoF score | 7 X 5 X 4=140 | 3 X 1 X 3=9 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/140*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/9*10)=2.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NSRP1 [Title/Abstract] AND ANKRD13B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NSRP1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | 21296756 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A2-A25B-01A | NSRP1 | chr17 | 28445191 | + | ANKRD13B | chr17 | 27934760 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000540900 | ENST00000394859 | NSRP1 | chr17 | 28445191 | + | ANKRD13B | chr17 | 27934760 | + |
| In-frame | ENST00000584423 | ENST00000394859 | NSRP1 | chr17 | 28445191 | + | ANKRD13B | chr17 | 27934760 | + |
| In-frame | ENST00000247026 | ENST00000394859 | NSRP1 | chr17 | 28445191 | + | ANKRD13B | chr17 | 27934760 | + |
| 3UTR-3CDS | ENST00000479218 | ENST00000394859 | NSRP1 | chr17 | 28445191 | + | ANKRD13B | chr17 | 27934760 | + |
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FusionProtFeatures for NSRP1_ANKRD13B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NSRP1 | ANKRD13B |