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Fusion gene ID: 24930 |
FusionGeneSummary for NSL1_TMEM206 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NSL1_TMEM206 | Fusion gene ID: 24930 | Hgene | Tgene | Gene symbol | NSL1 | TMEM206 | Gene ID | 284058 | 55248 |
| Gene name | KAT8 regulatory NSL complex subunit 1 | transmembrane protein 206 | |
| Synonyms | CENP-36|KDVS|KIAA1267|MSL1v1|NSL1|hMSL1v1 | C1orf75 | |
| Cytomap | 17q21.31 | 1q32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | KAT8 regulatory NSL complex subunit 1MLL1/MLL complex subunit KANSL1MSL1 homolog 1NSL complex protein NSL1centromere protein 36male-specific lethal 1 homolognon-specific lethal 1 homolog | transmembrane protein 206 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q96IY1 | Q9H813 | |
| Ensembl transtripts involved in fusion gene | ENST00000366978, ENST00000366977, ENST00000422588, ENST00000366975, ENST00000366976, ENST00000473995, | ENST00000261455, ENST00000535273, ENST00000471937, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: NSL1 [Title/Abstract] AND TMEM206 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NSL1 | GO:0043981 | histone H4-K5 acetylation | 20018852 |
| Hgene | NSL1 | GO:0043982 | histone H4-K8 acetylation | 20018852 |
| Hgene | NSL1 | GO:0043984 | histone H4-K16 acetylation | 20018852 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A18J-01A | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000366978 | ENST00000261455 | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
| Frame-shift | ENST00000366978 | ENST00000535273 | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
| 5CDS-5UTR | ENST00000366978 | ENST00000471937 | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
| In-frame | ENST00000366977 | ENST00000261455 | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
| In-frame | ENST00000366977 | ENST00000535273 | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
| 5CDS-5UTR | ENST00000366977 | ENST00000471937 | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
| Frame-shift | ENST00000422588 | ENST00000261455 | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
| Frame-shift | ENST00000422588 | ENST00000535273 | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
| 5CDS-5UTR | ENST00000422588 | ENST00000471937 | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
| intron-3CDS | ENST00000366975 | ENST00000261455 | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
| intron-3CDS | ENST00000366975 | ENST00000535273 | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
| intron-5UTR | ENST00000366975 | ENST00000471937 | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
| In-frame | ENST00000366976 | ENST00000261455 | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
| In-frame | ENST00000366976 | ENST00000535273 | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
| 5CDS-5UTR | ENST00000366976 | ENST00000471937 | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
| intron-3CDS | ENST00000473995 | ENST00000261455 | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
| intron-3CDS | ENST00000473995 | ENST00000535273 | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
| intron-5UTR | ENST00000473995 | ENST00000471937 | NSL1 | chr1 | 212955714 | - | TMEM206 | chr1 | 212560442 | - |
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FusionProtFeatures for NSL1_TMEM206 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NSL1 | TMEM206 |