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Fusion gene ID: 24926

FusionGeneSummary for NSG1_PTGR1

Fusion gene summary

Fusion gene information	Fusion gene name: NSG1_PTGR1
	Fusion gene ID: 24926
		Hgene	Tgene
	Gene symbol	NSG1	PTGR1
	Gene ID	27065	22949
	Gene name	neuronal vesicle trafficking associated 1	prostaglandin reductase 1
	Synonyms	D4S234\|D4S234E\|NEEP21\|P21	LTB4DH\|PGR1\|ZADH3
	Cytomap	4p16.3	9q31.3
	Type of gene	protein-coding	protein-coding
	Description	neuronal vesicle trafficking-associated protein 1brain neuron cytoplasmic protein 1carboxyterminally EE-tagged neuron-enriched endosomal 21 kDa proteinneuron specific gene family member 1neuron-enriched endosomal protein of 21 kDneuron-enriched endos	prostaglandin reductase 115-oxoprostaglandin 13-reductaseNADP-dependent leukotriene B4 12-hydroxydehydrogenasePRG-1leukotriene B4 12-hydroxydehydrogenasezinc binding alcohol dehydrogenase domain containing 3
	Modification date	20180523	20180519
	UniProtAcc	P42857	Q14914
	Ensembl transtripts involved in fusion gene	ENST00000421177, ENST00000513555, ENST00000450293, ENST00000505246, ENST00000506380, ENST00000397958, ENST00000433139, ENST00000504171,	ENST00000538962, ENST00000309195, ENST00000407693, ENST00000238248,
Fusion gene scores	* DoF score	3 X 3 X 1=9	3 X 3 X 3=27
	# samples	3	3
	** MAII score	log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: NSG1 [Title/Abstract] AND PTGR1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AA130861	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000421177	ENST00000538962	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000421177	ENST00000309195	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000421177	ENST00000407693	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000421177	ENST00000238248	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000513555	ENST00000538962	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000513555	ENST00000309195	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000513555	ENST00000407693	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000513555	ENST00000238248	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000450293	ENST00000538962	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000450293	ENST00000309195	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000450293	ENST00000407693	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000450293	ENST00000238248	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000505246	ENST00000538962	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000505246	ENST00000309195	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000505246	ENST00000407693	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000505246	ENST00000238248	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000506380	ENST00000538962	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000506380	ENST00000309195	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000506380	ENST00000407693	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000506380	ENST00000238248	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000397958	ENST00000538962	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000397958	ENST00000309195	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000397958	ENST00000407693	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000397958	ENST00000238248	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000433139	ENST00000538962	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000433139	ENST00000309195	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000433139	ENST00000407693	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000433139	ENST00000238248	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000504171	ENST00000538962	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000504171	ENST00000309195	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000504171	ENST00000407693	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+
intron-intron	ENST00000504171	ENST00000238248	NSG1	chr4	4355416	+	PTGR1	chr9	114351101	+

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FusionProtFeatures for NSG1_PTGR1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NSG1 P42857	PTGR1 Q14914

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Fusion gene ID: 24926

FusionGeneSummary for NSG1_PTGR1

FusionProtFeatures for NSG1_PTGR1