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Fusion gene ID: 24925 |
FusionGeneSummary for NSG1_MOB2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NSG1_MOB2 | Fusion gene ID: 24925 | Hgene | Tgene | Gene symbol | NSG1 | MOB2 | Gene ID | 27065 | 81532 |
| Gene name | neuronal vesicle trafficking associated 1 | MOB kinase activator 2 | |
| Synonyms | D4S234|D4S234E|NEEP21|P21 | HCCA2 | |
| Cytomap | 4p16.3 | 11p15.5 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neuronal vesicle trafficking-associated protein 1brain neuron cytoplasmic protein 1carboxyterminally EE-tagged neuron-enriched endosomal 21 kDa proteinneuron specific gene family member 1neuron-enriched endosomal protein of 21 kDneuron-enriched endos | MOB kinase activator 2MOB2 Mps One Binder homologMps one binder kinase activator-like 2 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P42857 | Q70IA6 | |
| Ensembl transtripts involved in fusion gene | ENST00000421177, ENST00000513555, ENST00000450293, ENST00000505246, ENST00000506380, ENST00000397958, ENST00000433139, ENST00000504171, | ENST00000329957, ENST00000526462, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 7 X 10 X 2=140 |
| # samples | 3 | 12 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/140*10)=-0.222392421336448 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NSG1 [Title/Abstract] AND MOB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI686628 | NSG1 | chr4 | 4419108 | - | MOB2 | chr11 | 1774705 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000421177 | ENST00000329957 | NSG1 | chr4 | 4419108 | - | MOB2 | chr11 | 1774705 | + |
| 5CDS-intron | ENST00000421177 | ENST00000526462 | NSG1 | chr4 | 4419108 | - | MOB2 | chr11 | 1774705 | + |
| 5CDS-intron | ENST00000513555 | ENST00000329957 | NSG1 | chr4 | 4419108 | - | MOB2 | chr11 | 1774705 | + |
| 5CDS-intron | ENST00000513555 | ENST00000526462 | NSG1 | chr4 | 4419108 | - | MOB2 | chr11 | 1774705 | + |
| intron-intron | ENST00000450293 | ENST00000329957 | NSG1 | chr4 | 4419108 | - | MOB2 | chr11 | 1774705 | + |
| intron-intron | ENST00000450293 | ENST00000526462 | NSG1 | chr4 | 4419108 | - | MOB2 | chr11 | 1774705 | + |
| 5CDS-intron | ENST00000505246 | ENST00000329957 | NSG1 | chr4 | 4419108 | - | MOB2 | chr11 | 1774705 | + |
| 5CDS-intron | ENST00000505246 | ENST00000526462 | NSG1 | chr4 | 4419108 | - | MOB2 | chr11 | 1774705 | + |
| 5CDS-intron | ENST00000506380 | ENST00000329957 | NSG1 | chr4 | 4419108 | - | MOB2 | chr11 | 1774705 | + |
| 5CDS-intron | ENST00000506380 | ENST00000526462 | NSG1 | chr4 | 4419108 | - | MOB2 | chr11 | 1774705 | + |
| 5CDS-intron | ENST00000397958 | ENST00000329957 | NSG1 | chr4 | 4419108 | - | MOB2 | chr11 | 1774705 | + |
| 5CDS-intron | ENST00000397958 | ENST00000526462 | NSG1 | chr4 | 4419108 | - | MOB2 | chr11 | 1774705 | + |
| 5CDS-intron | ENST00000433139 | ENST00000329957 | NSG1 | chr4 | 4419108 | - | MOB2 | chr11 | 1774705 | + |
| 5CDS-intron | ENST00000433139 | ENST00000526462 | NSG1 | chr4 | 4419108 | - | MOB2 | chr11 | 1774705 | + |
| 5CDS-intron | ENST00000504171 | ENST00000329957 | NSG1 | chr4 | 4419108 | - | MOB2 | chr11 | 1774705 | + |
| 5CDS-intron | ENST00000504171 | ENST00000526462 | NSG1 | chr4 | 4419108 | - | MOB2 | chr11 | 1774705 | + |
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FusionProtFeatures for NSG1_MOB2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NSG1 | MOB2 |