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Fusion gene ID: 24915 |
FusionGeneSummary for NSFL1C_EPSTI1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NSFL1C_EPSTI1 | Fusion gene ID: 24915 | Hgene | Tgene | Gene symbol | NSFL1C | EPSTI1 | Gene ID | 55968 | 94240 |
| Gene name | NSFL1 cofactor | epithelial stromal interaction 1 | |
| Synonyms | P47|UBX1|UBXD10|UBXN2C|dJ776F14.1 | BRESI1 | |
| Cytomap | 20p13 | 13q14.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NSFL1 cofactor p47NSFL1 (p97) cofactor (p47)SHP1 homologUBX domain-containing protein 2Cp97 cofactor p47 | epithelial-stromal interaction protein 1epithelial stromal interaction 1 (breast) | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9UNZ2 | Q96J88 | |
| Ensembl transtripts involved in fusion gene | ENST00000353088, ENST00000476071, ENST00000216879, ENST00000381658, ENST00000350991, ENST00000461211, | ENST00000313640, ENST00000313624, ENST00000398762, ENST00000476830, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 3 X 3=27 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NSFL1C [Title/Abstract] AND EPSTI1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-61-1911-01A | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000353088 | ENST00000313640 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| In-frame | ENST00000353088 | ENST00000313624 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| In-frame | ENST00000353088 | ENST00000398762 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| 5CDS-5UTR | ENST00000353088 | ENST00000476830 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| In-frame | ENST00000476071 | ENST00000313640 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| In-frame | ENST00000476071 | ENST00000313624 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| In-frame | ENST00000476071 | ENST00000398762 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| 5CDS-5UTR | ENST00000476071 | ENST00000476830 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| In-frame | ENST00000216879 | ENST00000313640 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| In-frame | ENST00000216879 | ENST00000313624 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| In-frame | ENST00000216879 | ENST00000398762 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| 5CDS-5UTR | ENST00000216879 | ENST00000476830 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| In-frame | ENST00000381658 | ENST00000313640 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| In-frame | ENST00000381658 | ENST00000313624 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| In-frame | ENST00000381658 | ENST00000398762 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| 5CDS-5UTR | ENST00000381658 | ENST00000476830 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| In-frame | ENST00000350991 | ENST00000313640 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| In-frame | ENST00000350991 | ENST00000313624 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| In-frame | ENST00000350991 | ENST00000398762 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| 5CDS-5UTR | ENST00000350991 | ENST00000476830 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| 5UTR-3CDS | ENST00000461211 | ENST00000313640 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| 5UTR-3CDS | ENST00000461211 | ENST00000313624 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| 5UTR-3CDS | ENST00000461211 | ENST00000398762 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
| 5UTR-5UTR | ENST00000461211 | ENST00000476830 | NSFL1C | chr20 | 1435612 | - | EPSTI1 | chr13 | 43528157 | - |
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FusionProtFeatures for NSFL1C_EPSTI1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NSFL1C | EPSTI1 |