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Fusion gene ID: 24890

FusionGeneSummary for NRXN3_TSHR

Fusion gene summary

Fusion gene information	Fusion gene name: NRXN3_TSHR
	Fusion gene ID: 24890
		Hgene	Tgene
	Gene symbol	NRXN3	TSHR
	Gene ID	9369	7253
	Gene name	neurexin 3	thyroid stimulating hormone receptor
	Synonyms	C14orf60	CHNG1\|LGR3\|hTSHR-I
	Cytomap	14q24.3-q31.1	14q31.1
	Type of gene	protein-coding	protein-coding
	Description	neurexin 3neurexin IIIneurexin-3-alpha	thyrotropin receptorTSH receptorseven transmembrane helix receptorthyrotropin receptor-I, hTSHR-I
	Modification date	20180519	20180523
	UniProtAcc	Q9Y4C0	P16473
	Ensembl transtripts involved in fusion gene	ENST00000554719, ENST00000335750, ENST00000557594, ENST00000281127, ENST00000428277, ENST00000556003,	ENST00000541158, ENST00000342443, ENST00000298171, ENST00000554263, ENST00000554435, ENST00000557096,
Fusion gene scores	* DoF score	5 X 6 X 3=90	5 X 3 X 5=75
	# samples	6	5
	** MAII score	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NRXN3 [Title/Abstract] AND TSHR [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LGG	TCGA-S9-A89Z-01A	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000554719	ENST00000541158	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
Frame-shift	ENST00000554719	ENST00000342443	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
Frame-shift	ENST00000554719	ENST00000298171	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
Frame-shift	ENST00000554719	ENST00000554263	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
Frame-shift	ENST00000554719	ENST00000554435	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
5CDS-intron	ENST00000554719	ENST00000557096	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
Frame-shift	ENST00000335750	ENST00000541158	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
Frame-shift	ENST00000335750	ENST00000342443	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
Frame-shift	ENST00000335750	ENST00000298171	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
Frame-shift	ENST00000335750	ENST00000554263	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
Frame-shift	ENST00000335750	ENST00000554435	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
5CDS-intron	ENST00000335750	ENST00000557096	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000557594	ENST00000541158	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000557594	ENST00000342443	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000557594	ENST00000298171	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000557594	ENST00000554263	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000557594	ENST00000554435	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-intron	ENST00000557594	ENST00000557096	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000281127	ENST00000541158	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000281127	ENST00000342443	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000281127	ENST00000298171	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000281127	ENST00000554263	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000281127	ENST00000554435	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-intron	ENST00000281127	ENST00000557096	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000428277	ENST00000541158	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000428277	ENST00000342443	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000428277	ENST00000298171	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000428277	ENST00000554263	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000428277	ENST00000554435	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-intron	ENST00000428277	ENST00000557096	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000556003	ENST00000541158	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000556003	ENST00000342443	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000556003	ENST00000298171	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000556003	ENST00000554263	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-3CDS	ENST00000556003	ENST00000554435	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+
intron-intron	ENST00000556003	ENST00000557096	NRXN3	chr14	79454484	+	TSHR	chr14	81528492	+

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FusionProtFeatures for NRXN3_TSHR

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NRXN3 Q9Y4C0	TSHR P16473

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Fusion gene ID: 24890

FusionGeneSummary for NRXN3_TSHR

FusionProtFeatures for NRXN3_TSHR