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Fusion gene ID: 24858 |
FusionGeneSummary for NRIP1_C21orf91 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NRIP1_C21orf91 | Fusion gene ID: 24858 | Hgene | Tgene | Gene symbol | NRIP1 | C21orf91 | Gene ID | 8204 | 54149 |
| Gene name | nuclear receptor interacting protein 1 | chromosome 21 open reading frame 91 | |
| Synonyms | RIP140 | C21orf14|C21orf38|CSSG1|EURL|YG81 | |
| Cytomap | 21q11.2-q21.1 | 21q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear receptor-interacting protein 1nuclear factor RIP140receptor-interacting protein 140 | protein EURL homologcold sore susceptibility gene 1early undifferentiated retina and lens | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P48552 | ||
| Ensembl transtripts involved in fusion gene | ENST00000318948, ENST00000400199, ENST00000400202, | ENST00000284881, ENST00000400559, ENST00000400558, ENST00000493464, | |
| Fusion gene scores | * DoF score | 10 X 3 X 7=210 | 1 X 1 X 1=1 |
| # samples | 10 | 1 | |
| ** MAII score | log2(10/210*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: NRIP1 [Title/Abstract] AND C21orf91 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NRIP1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10364267 |
| Hgene | NRIP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7641693|10364267 |
| Hgene | NRIP1 | GO:0071392 | cellular response to estradiol stimulus | 15831516 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-E7-A7DV-01A | NRIP1 | chr21 | 16437066 | - | C21orf91 | chr21 | 19165898 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000318948 | ENST00000284881 | NRIP1 | chr21 | 16437066 | - | C21orf91 | chr21 | 19165898 | - |
| 5UTR-3CDS | ENST00000318948 | ENST00000400559 | NRIP1 | chr21 | 16437066 | - | C21orf91 | chr21 | 19165898 | - |
| 5UTR-3CDS | ENST00000318948 | ENST00000400558 | NRIP1 | chr21 | 16437066 | - | C21orf91 | chr21 | 19165898 | - |
| 5UTR-intron | ENST00000318948 | ENST00000493464 | NRIP1 | chr21 | 16437066 | - | C21orf91 | chr21 | 19165898 | - |
| 5UTR-3CDS | ENST00000400199 | ENST00000284881 | NRIP1 | chr21 | 16437066 | - | C21orf91 | chr21 | 19165898 | - |
| 5UTR-3CDS | ENST00000400199 | ENST00000400559 | NRIP1 | chr21 | 16437066 | - | C21orf91 | chr21 | 19165898 | - |
| 5UTR-3CDS | ENST00000400199 | ENST00000400558 | NRIP1 | chr21 | 16437066 | - | C21orf91 | chr21 | 19165898 | - |
| 5UTR-intron | ENST00000400199 | ENST00000493464 | NRIP1 | chr21 | 16437066 | - | C21orf91 | chr21 | 19165898 | - |
| 5UTR-3CDS | ENST00000400202 | ENST00000284881 | NRIP1 | chr21 | 16437066 | - | C21orf91 | chr21 | 19165898 | - |
| 5UTR-3CDS | ENST00000400202 | ENST00000400559 | NRIP1 | chr21 | 16437066 | - | C21orf91 | chr21 | 19165898 | - |
| 5UTR-3CDS | ENST00000400202 | ENST00000400558 | NRIP1 | chr21 | 16437066 | - | C21orf91 | chr21 | 19165898 | - |
| 5UTR-intron | ENST00000400202 | ENST00000493464 | NRIP1 | chr21 | 16437066 | - | C21orf91 | chr21 | 19165898 | - |
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FusionProtFeatures for NRIP1_C21orf91 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NRIP1 | C21orf91 |