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Fusion gene ID: 24843 |
FusionGeneSummary for NRF1_RHEB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NRF1_RHEB | Fusion gene ID: 24843 | Hgene | Tgene | Gene symbol | NRF1 | RHEB | Gene ID | 4899 | 6009 |
| Gene name | nuclear respiratory factor 1 | Ras homolog, mTORC1 binding | |
| Synonyms | ALPHA-PAL | RHEB2 | |
| Cytomap | 7q32.2 | 7q36.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear respiratory factor 1alpha palindromic-binding protein | GTP-binding protein RhebRas homolog enriched in brain 2 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q16656 | Q15382 | |
| Ensembl transtripts involved in fusion gene | ENST00000393232, ENST00000353868, ENST00000539636, ENST00000311967, ENST00000223190, ENST00000393230, ENST00000393231, ENST00000477428, | ENST00000262187, ENST00000472642, ENST00000496004, | |
| Fusion gene scores | * DoF score | 8 X 5 X 4=160 | 5 X 5 X 4=100 |
| # samples | 8 | 5 | |
| ** MAII score | log2(8/160*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NRF1 [Title/Abstract] AND RHEB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-D3-A3C3-06A | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000393232 | ENST00000262187 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| 5CDS-5UTR | ENST00000393232 | ENST00000472642 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| 5CDS-5UTR | ENST00000393232 | ENST00000496004 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| Frame-shift | ENST00000353868 | ENST00000262187 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| 5CDS-5UTR | ENST00000353868 | ENST00000472642 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| 5CDS-5UTR | ENST00000353868 | ENST00000496004 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| Frame-shift | ENST00000539636 | ENST00000262187 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| 5CDS-5UTR | ENST00000539636 | ENST00000472642 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| 5CDS-5UTR | ENST00000539636 | ENST00000496004 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| Frame-shift | ENST00000311967 | ENST00000262187 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| 5CDS-5UTR | ENST00000311967 | ENST00000472642 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| 5CDS-5UTR | ENST00000311967 | ENST00000496004 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| Frame-shift | ENST00000223190 | ENST00000262187 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| 5CDS-5UTR | ENST00000223190 | ENST00000472642 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| 5CDS-5UTR | ENST00000223190 | ENST00000496004 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| Frame-shift | ENST00000393230 | ENST00000262187 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| 5CDS-5UTR | ENST00000393230 | ENST00000472642 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| 5CDS-5UTR | ENST00000393230 | ENST00000496004 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| Frame-shift | ENST00000393231 | ENST00000262187 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| 5CDS-5UTR | ENST00000393231 | ENST00000472642 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| 5CDS-5UTR | ENST00000393231 | ENST00000496004 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| intron-3CDS | ENST00000477428 | ENST00000262187 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| intron-5UTR | ENST00000477428 | ENST00000472642 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
| intron-5UTR | ENST00000477428 | ENST00000496004 | NRF1 | chr7 | 129357216 | + | RHEB | chr7 | 151181890 | - |
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FusionProtFeatures for NRF1_RHEB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NRF1 | RHEB |