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Fusion gene ID: 24819

FusionGeneSummary for NRBF2_RAPH1

Fusion gene summary

Fusion gene information	Fusion gene name: NRBF2_RAPH1
	Fusion gene ID: 24819
		Hgene	Tgene
	Gene symbol	NRBF2	RAPH1
	Gene ID	29982	65059
	Gene name	nuclear receptor binding factor 2	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
	Synonyms	COPR\|COPR1\|COPR2\|NRBF-2	ALS2CR18\|ALS2CR9\|LPD\|PREL-2\|PREL2\|RMO1\|RalGDS/AF-6
	Cytomap	10q21.3	2q33.2
	Type of gene	protein-coding	protein-coding
	Description	nuclear receptor-binding factor 2comodulator of PPAR and RXR 1comodulator of PPAR and RXR 2	ras-associated and pleckstrin homology domains-containing protein 1amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 18amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 9lamellipodinproline-rich EVH1 ligand
	Modification date	20180519	20180519
	UniProtAcc	Q96F24	Q70E73
	Ensembl transtripts involved in fusion gene	ENST00000277746, ENST00000435510,	ENST00000457812, ENST00000319170, ENST00000374493, ENST00000374489, ENST00000374488, ENST00000308091, ENST00000419464, ENST00000423104, ENST00000439222, ENST00000453034, ENST00000418114,
Fusion gene scores	* DoF score	5 X 4 X 3=60	1 X 1 X 1=1
	# samples	5	1
	** MAII score	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: NRBF2 [Title/Abstract] AND RAPH1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF986118	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000277746	ENST00000457812	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000277746	ENST00000319170	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000277746	ENST00000374493	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000277746	ENST00000374489	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000277746	ENST00000374488	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000277746	ENST00000308091	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000277746	ENST00000419464	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000277746	ENST00000423104	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000277746	ENST00000439222	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000277746	ENST00000453034	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000277746	ENST00000418114	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000435510	ENST00000457812	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000435510	ENST00000319170	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000435510	ENST00000374493	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000435510	ENST00000374489	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000435510	ENST00000374488	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000435510	ENST00000308091	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000435510	ENST00000419464	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000435510	ENST00000423104	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000435510	ENST00000439222	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000435510	ENST00000453034	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+
intron-intron	ENST00000435510	ENST00000418114	NRBF2	chr10	64896545	-	RAPH1	chr2	204355155	+

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FusionProtFeatures for NRBF2_RAPH1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NRBF2 Q96F24	RAPH1 Q70E73

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Fusion gene ID: 24819

FusionGeneSummary for NRBF2_RAPH1

FusionProtFeatures for NRBF2_RAPH1