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Fusion gene ID: 24805 |
FusionGeneSummary for NR3C2_SPATA17 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NR3C2_SPATA17 | Fusion gene ID: 24805 | Hgene | Tgene | Gene symbol | NR3C2 | SPATA17 | Gene ID | 4306 | 128153 |
| Gene name | nuclear receptor subfamily 3 group C member 2 | spermatogenesis associated 17 | |
| Synonyms | MCR|MLR|MR|NR3C2VIT | IQCH|MSRG-11|MSRG11 | |
| Cytomap | 4q31.23 | 1q41 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mineralocorticoid receptoraldosterone receptormineralocorticoid receptor 1mineralocorticoid receptor 2mineralocorticoid receptor deltanuclear receptor subfamily 3, group C, member 2 variant 3 | spermatogenesis-associated protein 17IQ motif containing Hspermatogenesis-related protein 11 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P08235 | Q96L03 | |
| Ensembl transtripts involved in fusion gene | ENST00000344721, ENST00000355292, ENST00000358102, ENST00000512865, ENST00000511528, ENST00000503313, | ENST00000366933, ENST00000471021, | |
| Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 6 X 6 X 6=216 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/216*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NR3C2 [Title/Abstract] AND SPATA17 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | CHOL | TCGA-W5-AA2T-01A | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000344721 | ENST00000366933 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
| 5CDS-3UTR | ENST00000344721 | ENST00000471021 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
| Frame-shift | ENST00000355292 | ENST00000366933 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
| 5CDS-3UTR | ENST00000355292 | ENST00000471021 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
| Frame-shift | ENST00000358102 | ENST00000366933 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
| 5CDS-3UTR | ENST00000358102 | ENST00000471021 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
| Frame-shift | ENST00000512865 | ENST00000366933 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
| 5CDS-3UTR | ENST00000512865 | ENST00000471021 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
| Frame-shift | ENST00000511528 | ENST00000366933 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
| 5CDS-3UTR | ENST00000511528 | ENST00000471021 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
| intron-3CDS | ENST00000503313 | ENST00000366933 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
| intron-3UTR | ENST00000503313 | ENST00000471021 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
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FusionProtFeatures for NR3C2_SPATA17 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NR3C2 | SPATA17 |