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Fusion gene ID: 24742

FusionGeneSummary for NPM2_CDC16

Fusion gene summary

Fusion gene information	Fusion gene name: NPM2_CDC16
	Fusion gene ID: 24742
		Hgene	Tgene
	Gene symbol	NPM2	CDC16
	Gene ID	10361	8881
	Gene name	nucleophosmin/nucleoplasmin 2	cell division cycle 16
	Synonyms	-	ANAPC6\|APC6\|CDC16Hs\|CUT9
	Cytomap	8p21.3	13q34
	Type of gene	protein-coding	protein-coding
	Description	nucleoplasmin-2	cell division cycle protein 16 homologanaphase-promoting complex, subunit 6cell division cycle 16 homologcyclosome subunit 6
	Modification date	20180523	20180522
	UniProtAcc	Q86SE8	Q13042
	Ensembl transtripts involved in fusion gene	ENST00000521157, ENST00000397940, ENST00000518119, ENST00000520180, ENST00000289820, ENST00000381530,	ENST00000375312, ENST00000360383, ENST00000356221, ENST00000375310, ENST00000375308, ENST00000252457, ENST00000252458, ENST00000461716,
Fusion gene scores	* DoF score	1 X 1 X 1=1	4 X 6 X 6=144
	# samples	1	9
	** MAII score	log2(1/1*10)=3.32192809488736	log2(9/144*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NPM2 [Title/Abstract] AND CDC16 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NPM2	GO:0006338	chromatin remodeling	12714744
Tgene	CDC16	GO:0070979	protein K11-linked ubiquitination	18485873

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			DA246675	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000521157	ENST00000375312	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000521157	ENST00000360383	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000521157	ENST00000356221	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000521157	ENST00000375310	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000521157	ENST00000375308	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000521157	ENST00000252457	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000521157	ENST00000252458	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
5CDS-intron	ENST00000521157	ENST00000461716	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000397940	ENST00000375312	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000397940	ENST00000360383	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000397940	ENST00000356221	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000397940	ENST00000375310	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000397940	ENST00000375308	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000397940	ENST00000252457	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000397940	ENST00000252458	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
5CDS-intron	ENST00000397940	ENST00000461716	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000518119	ENST00000375312	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000518119	ENST00000360383	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000518119	ENST00000356221	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000518119	ENST00000375310	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000518119	ENST00000375308	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000518119	ENST00000252457	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000518119	ENST00000252458	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
5CDS-intron	ENST00000518119	ENST00000461716	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
intron-3CDS	ENST00000520180	ENST00000375312	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
intron-3CDS	ENST00000520180	ENST00000360383	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
intron-3CDS	ENST00000520180	ENST00000356221	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
intron-3CDS	ENST00000520180	ENST00000375310	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
intron-3CDS	ENST00000520180	ENST00000375308	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
intron-3CDS	ENST00000520180	ENST00000252457	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
intron-3CDS	ENST00000520180	ENST00000252458	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
intron-intron	ENST00000520180	ENST00000461716	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000289820	ENST00000375312	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000289820	ENST00000360383	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000289820	ENST00000356221	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000289820	ENST00000375310	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000289820	ENST00000375308	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000289820	ENST00000252457	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
In-frame	ENST00000289820	ENST00000252458	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
5CDS-intron	ENST00000289820	ENST00000461716	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
Frame-shift	ENST00000381530	ENST00000375312	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
Frame-shift	ENST00000381530	ENST00000360383	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
Frame-shift	ENST00000381530	ENST00000356221	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
Frame-shift	ENST00000381530	ENST00000375310	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
Frame-shift	ENST00000381530	ENST00000375308	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
Frame-shift	ENST00000381530	ENST00000252457	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
Frame-shift	ENST00000381530	ENST00000252458	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+
5CDS-intron	ENST00000381530	ENST00000461716	NPM2	chr8	21892055	+	CDC16	chr13	115028352	+

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FusionProtFeatures for NPM2_CDC16

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NPM2 Q86SE8	CDC16 Q13042

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Fusion gene ID: 24742

FusionGeneSummary for NPM2_CDC16

FusionProtFeatures for NPM2_CDC16