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Fusion gene ID: 2472

FusionGeneSummary for ARHGAP5_KIAA0391

Fusion gene summary

Fusion gene information	Fusion gene name: ARHGAP5_KIAA0391
	Fusion gene ID: 2472
		Hgene	Tgene
	Gene symbol	ARHGAP5	KIAA0391
	Gene ID	394	9692
	Gene name	Rho GTPase activating protein 5	KIAA0391
	Synonyms	GFI2\|RhoGAP5\|p190-B\|p190BRhoGAP	MRPP3\|PRORP
	Cytomap	14q12	14q13.2
	Type of gene	protein-coding	protein-coding
	Description	rho GTPase-activating protein 5growth factor independent 2p100 RasGAP-associated p105 proteinp105 RhoGAPrho-type GTPase-activating protein 5	mitochondrial ribonuclease P catalytic subunitmitochondrial RNase P protein 3mitochondrial RNase P subunit 3mitochondrial ribonuclease P protein 3proteinaceous RNase P
	Modification date	20180523	20180523
	UniProtAcc	Q13017	O15091
	Ensembl transtripts involved in fusion gene	ENST00000556611, ENST00000539826, ENST00000396582, ENST00000432921, ENST00000345122, ENST00000433497,	ENST00000604948, ENST00000557565, ENST00000250377, ENST00000321130, ENST00000534898, ENST00000603544, ENST00000605870, ENST00000603588,
Fusion gene scores	* DoF score	9 X 4 X 7=252	10 X 5 X 6=300
	# samples	10	11
	** MAII score	log2(10/252*10)=-1.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/300*10)=-1.44745897697122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ARHGAP5 [Title/Abstract] AND KIAA0391 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	KIAA0391	GO:0097745	mitochondrial tRNA 5'-end processing	25953853

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	LUAD	TCGA-MP-A4T6-01A	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000556611	ENST00000604948	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
In-frame	ENST00000556611	ENST00000557565	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000556611	ENST00000250377	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000556611	ENST00000321130	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000556611	ENST00000534898	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
In-frame	ENST00000556611	ENST00000603544	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000556611	ENST00000605870	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
5CDS-intron	ENST00000556611	ENST00000603588	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000539826	ENST00000604948	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
In-frame	ENST00000539826	ENST00000557565	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000539826	ENST00000250377	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000539826	ENST00000321130	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000539826	ENST00000534898	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
In-frame	ENST00000539826	ENST00000603544	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000539826	ENST00000605870	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
5CDS-intron	ENST00000539826	ENST00000603588	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
intron-3CDS	ENST00000396582	ENST00000604948	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
intron-3CDS	ENST00000396582	ENST00000557565	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
intron-3CDS	ENST00000396582	ENST00000250377	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
intron-3CDS	ENST00000396582	ENST00000321130	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
intron-3CDS	ENST00000396582	ENST00000534898	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
intron-3CDS	ENST00000396582	ENST00000603544	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
intron-3CDS	ENST00000396582	ENST00000605870	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
intron-intron	ENST00000396582	ENST00000603588	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000432921	ENST00000604948	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
In-frame	ENST00000432921	ENST00000557565	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000432921	ENST00000250377	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000432921	ENST00000321130	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000432921	ENST00000534898	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
In-frame	ENST00000432921	ENST00000603544	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000432921	ENST00000605870	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
5CDS-intron	ENST00000432921	ENST00000603588	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000345122	ENST00000604948	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
In-frame	ENST00000345122	ENST00000557565	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000345122	ENST00000250377	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000345122	ENST00000321130	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000345122	ENST00000534898	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
In-frame	ENST00000345122	ENST00000603544	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000345122	ENST00000605870	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
5CDS-intron	ENST00000345122	ENST00000603588	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000433497	ENST00000604948	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
In-frame	ENST00000433497	ENST00000557565	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000433497	ENST00000250377	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000433497	ENST00000321130	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000433497	ENST00000534898	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
In-frame	ENST00000433497	ENST00000603544	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
Frame-shift	ENST00000433497	ENST00000605870	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+
5CDS-intron	ENST00000433497	ENST00000603588	ARHGAP5	chr14	32586493	+	KIAA0391	chr14	35742641	+

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FusionProtFeatures for ARHGAP5_KIAA0391

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARHGAP5 Q13017	KIAA0391 O15091

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Fusion gene ID: 2472

FusionGeneSummary for ARHGAP5_KIAA0391

FusionProtFeatures for ARHGAP5_KIAA0391