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Fusion gene ID: 24690

FusionGeneSummary for NPEPPS_KPNB1

Fusion gene summary

Fusion gene information	Fusion gene name: NPEPPS_KPNB1
	Fusion gene ID: 24690
		Hgene	Tgene
	Gene symbol	NPEPPS	KPNB1
	Gene ID	9520	3837
	Gene name	aminopeptidase puromycin sensitive	karyopherin subunit beta 1
	Synonyms	AAP-S\|MP100\|PSA	IMB1\|IPO1\|IPOB\|Impnb\|NTF97
	Cytomap	17q21.32	17q21.32
	Type of gene	protein-coding	protein-coding
	Description	puromycin-sensitive aminopeptidasecytosol alanyl aminopeptidasemetalloproteinase MP100	importin subunit beta-1PTAC97importin 1importin 90importin beta-1 subunitkaryopherin (importin) beta 1nuclear factor p97pore targeting complex 97 kDa subunit
	Modification date	20180523	20180523
	UniProtAcc	P55786	Q14974
	Ensembl transtripts involved in fusion gene	ENST00000525037, ENST00000530173, ENST00000322157, ENST00000544660,	ENST00000535458, ENST00000290158, ENST00000540627, ENST00000537679, ENST00000577918,
Fusion gene scores	* DoF score	9 X 6 X 7=378	9 X 10 X 5=450
	# samples	10	10
	** MAII score	log2(10/378*10)=-1.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/450*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NPEPPS [Title/Abstract] AND KPNB1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NPEPPS	GO:0071456	cellular response to hypoxia	21056661
Tgene	KPNB1	GO:0006606	protein import into nucleus	15964792
Tgene	KPNB1	GO:0006610	ribosomal protein import into nucleus	9687515

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	LUAD	TCGA-78-8648-01A	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000525037	ENST00000535458	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
intron-3CDS	ENST00000525037	ENST00000290158	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
intron-3CDS	ENST00000525037	ENST00000540627	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
intron-3CDS	ENST00000525037	ENST00000537679	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
intron-intron	ENST00000525037	ENST00000577918	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
In-frame	ENST00000530173	ENST00000535458	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
In-frame	ENST00000530173	ENST00000290158	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
In-frame	ENST00000530173	ENST00000540627	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
In-frame	ENST00000530173	ENST00000537679	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
5CDS-intron	ENST00000530173	ENST00000577918	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
In-frame	ENST00000322157	ENST00000535458	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
In-frame	ENST00000322157	ENST00000290158	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
In-frame	ENST00000322157	ENST00000540627	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
In-frame	ENST00000322157	ENST00000537679	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
5CDS-intron	ENST00000322157	ENST00000577918	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
In-frame	ENST00000544660	ENST00000535458	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
In-frame	ENST00000544660	ENST00000290158	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
In-frame	ENST00000544660	ENST00000540627	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
In-frame	ENST00000544660	ENST00000537679	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+
5CDS-intron	ENST00000544660	ENST00000577918	NPEPPS	chr17	45608921	+	KPNB1	chr17	45740455	+

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FusionProtFeatures for NPEPPS_KPNB1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NPEPPS P55786	KPNB1 Q14974

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Fusion gene ID: 24690

FusionGeneSummary for NPEPPS_KPNB1

FusionProtFeatures for NPEPPS_KPNB1