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Fusion gene ID: 24667 |
FusionGeneSummary for NPAS3_AKAP6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NPAS3_AKAP6 | Fusion gene ID: 24667 | Hgene | Tgene | Gene symbol | NPAS3 | AKAP6 | Gene ID | 64067 | 9472 |
| Gene name | neuronal PAS domain protein 3 | A-kinase anchoring protein 6 | |
| Synonyms | MOP6|PASD6|bHLHe12 | ADAP100|ADAP6|AKAP100|PRKA6|mAKAP | |
| Cytomap | 14q13.1 | 14q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neuronal PAS domain-containing protein 3PAS domain-containing protein 6basic-helix-loop-helix-PAS protein MOP6class E basic helix-loop-helix protein 12member of PAS protein 6neuronal PAS3 | A-kinase anchor protein 6A kinase (PRKA) anchor protein 6A-kinase anchor protein 100 kDaAKAP 100AKAP-6protein kinase A anchoring protein 6 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8IXF0 | Q13023 | |
| Ensembl transtripts involved in fusion gene | ENST00000551492, ENST00000346562, ENST00000341321, ENST00000548645, ENST00000356141, ENST00000357798, ENST00000547068, ENST00000551008, ENST00000550662, | ENST00000280979, ENST00000557354, ENST00000557272, ENST00000554449, | |
| Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 10 X 8 X 7=560 |
| # samples | 6 | 12 | |
| ** MAII score | log2(6/60*10)=0 | log2(12/560*10)=-2.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NPAS3 [Title/Abstract] AND AKAP6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | AKAP6 | GO:0060306 | regulation of membrane repolarization | 11299204 |
| Tgene | AKAP6 | GO:0071320 | cellular response to cAMP | 11299204 |
| Tgene | AKAP6 | GO:1901381 | positive regulation of potassium ion transmembrane transport | 11299204 |
| Tgene | AKAP6 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity | 11299204 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-55-7913-01B | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| TCGA | RV | OV | TCGA-25-1326-01A | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000551492 | ENST00000280979 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| intron-3CDS | ENST00000551492 | ENST00000557354 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| intron-3CDS | ENST00000551492 | ENST00000557272 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| intron-intron | ENST00000551492 | ENST00000554449 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| Frame-shift | ENST00000346562 | ENST00000280979 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| Frame-shift | ENST00000346562 | ENST00000557354 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| Frame-shift | ENST00000346562 | ENST00000557272 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| 5CDS-intron | ENST00000346562 | ENST00000554449 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| Frame-shift | ENST00000341321 | ENST00000280979 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| Frame-shift | ENST00000341321 | ENST00000557354 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| Frame-shift | ENST00000341321 | ENST00000557272 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| 5CDS-intron | ENST00000341321 | ENST00000554449 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| Frame-shift | ENST00000548645 | ENST00000280979 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| Frame-shift | ENST00000548645 | ENST00000557354 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| Frame-shift | ENST00000548645 | ENST00000557272 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| 5CDS-intron | ENST00000548645 | ENST00000554449 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| Frame-shift | ENST00000356141 | ENST00000280979 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| Frame-shift | ENST00000356141 | ENST00000557354 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| Frame-shift | ENST00000356141 | ENST00000557272 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| 5CDS-intron | ENST00000356141 | ENST00000554449 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| Frame-shift | ENST00000357798 | ENST00000280979 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| Frame-shift | ENST00000357798 | ENST00000557354 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| Frame-shift | ENST00000357798 | ENST00000557272 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| 5CDS-intron | ENST00000357798 | ENST00000554449 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| intron-3CDS | ENST00000547068 | ENST00000280979 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| intron-3CDS | ENST00000547068 | ENST00000557354 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| intron-3CDS | ENST00000547068 | ENST00000557272 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| intron-intron | ENST00000547068 | ENST00000554449 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| intron-3CDS | ENST00000551008 | ENST00000280979 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| intron-3CDS | ENST00000551008 | ENST00000557354 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| intron-3CDS | ENST00000551008 | ENST00000557272 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| intron-intron | ENST00000551008 | ENST00000554449 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| intron-3CDS | ENST00000550662 | ENST00000280979 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| intron-3CDS | ENST00000550662 | ENST00000557354 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| intron-3CDS | ENST00000550662 | ENST00000557272 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| intron-intron | ENST00000550662 | ENST00000554449 | NPAS3 | chr14 | 33408572 | + | AKAP6 | chr14 | 33147517 | + |
| Frame-shift | ENST00000551492 | ENST00000280979 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| 5CDS-intron | ENST00000551492 | ENST00000557354 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| 5CDS-intron | ENST00000551492 | ENST00000557272 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| 5CDS-intron | ENST00000551492 | ENST00000554449 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-3CDS | ENST00000346562 | ENST00000280979 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-intron | ENST00000346562 | ENST00000557354 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-intron | ENST00000346562 | ENST00000557272 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-intron | ENST00000346562 | ENST00000554449 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| Frame-shift | ENST00000341321 | ENST00000280979 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| 5CDS-intron | ENST00000341321 | ENST00000557354 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| 5CDS-intron | ENST00000341321 | ENST00000557272 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| 5CDS-intron | ENST00000341321 | ENST00000554449 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-3CDS | ENST00000548645 | ENST00000280979 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-intron | ENST00000548645 | ENST00000557354 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-intron | ENST00000548645 | ENST00000557272 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-intron | ENST00000548645 | ENST00000554449 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| Frame-shift | ENST00000356141 | ENST00000280979 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| 5CDS-intron | ENST00000356141 | ENST00000557354 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| 5CDS-intron | ENST00000356141 | ENST00000557272 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| 5CDS-intron | ENST00000356141 | ENST00000554449 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-3CDS | ENST00000357798 | ENST00000280979 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-intron | ENST00000357798 | ENST00000557354 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-intron | ENST00000357798 | ENST00000557272 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-intron | ENST00000357798 | ENST00000554449 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-3CDS | ENST00000547068 | ENST00000280979 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-intron | ENST00000547068 | ENST00000557354 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-intron | ENST00000547068 | ENST00000557272 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-intron | ENST00000547068 | ENST00000554449 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-3CDS | ENST00000551008 | ENST00000280979 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-intron | ENST00000551008 | ENST00000557354 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-intron | ENST00000551008 | ENST00000557272 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-intron | ENST00000551008 | ENST00000554449 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-3CDS | ENST00000550662 | ENST00000280979 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-intron | ENST00000550662 | ENST00000557354 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-intron | ENST00000550662 | ENST00000557272 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
| intron-intron | ENST00000550662 | ENST00000554449 | NPAS3 | chr14 | 33525200 | + | AKAP6 | chr14 | 33290608 | + |
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FusionProtFeatures for NPAS3_AKAP6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NPAS3 | AKAP6 |