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Fusion gene ID: 24661 |
FusionGeneSummary for NPAS2_CNOT11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NPAS2_CNOT11 | Fusion gene ID: 24661 | Hgene | Tgene | Gene symbol | NPAS2 | CNOT11 | Gene ID | 4862 | 55571 |
| Gene name | neuronal PAS domain protein 2 | CCR4-NOT transcription complex subunit 11 | |
| Synonyms | MOP4|PASD4|bHLHe9 | C2orf29|C40 | |
| Cytomap | 2q11.2 | 2q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neuronal PAS domain-containing protein 2PAS domain-containing protein 4basic-helix-loop-helix-PAS protein MOP4class E basic helix-loop-helix protein 9member of PAS protein 4member of PAS superfamily 4neuronal PAS2 | CCR4-NOT transcription complex subunit 11UPF0760 protein C2orf29 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q99743 | Q9UKZ1 | |
| Ensembl transtripts involved in fusion gene | ENST00000335681, ENST00000542504, ENST00000486017, | ENST00000289382, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: NPAS2 [Title/Abstract] AND CNOT11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NPAS2 | GO:0045893 | positive regulation of transcription, DNA-templated | 11441146 |
| Hgene | NPAS2 | GO:0051775 | response to redox state | 11441146 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-DK-A3IK-01A | NPAS2 | chr2 | 101565942 | + | CNOT11 | chr2 | 101879001 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000335681 | ENST00000289382 | NPAS2 | chr2 | 101565942 | + | CNOT11 | chr2 | 101879001 | + |
| In-frame | ENST00000542504 | ENST00000289382 | NPAS2 | chr2 | 101565942 | + | CNOT11 | chr2 | 101879001 | + |
| 3UTR-3CDS | ENST00000486017 | ENST00000289382 | NPAS2 | chr2 | 101565942 | + | CNOT11 | chr2 | 101879001 | + |
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FusionProtFeatures for NPAS2_CNOT11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NPAS2 | CNOT11 |
| Transcriptional activator which forms a core componentof the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes throughthe generation of approximately 24 hour circadian rhythms in geneexpression, which are translated into rhythms in metabolism andbehavior. It is derived from the Latin roots 'circa' (about) and'diem' (day) and acts as an important regulator of a wide array ofphysiological functions including metabolism, sleep, bodytemperature, blood pressure, endocrine, immune, cardiovascular,and renal function. Consists of two major components: the centralclock, residing in the suprachiasmatic nucleus (SCN) of the brain,and the peripheral clocks that are present in nearly every tissueand organ system. Both the central and peripheral clocks can bereset by environmental cues, also known as Zeitgebers (German for'timegivers'). The predominant Zeitgeber for the central clock islight, which is sensed by retina and signals directly to the SCN.The central clock entrains the peripheral clocks through neuronaland hormonal signals, body temperature and feeding-related cues,aligning all clocks with the external light/dark cycle. Circadianrhythms allow an organism to achieve temporal homeostasis with itsenvironment at the molecular level by regulating gene expressionto create a peak of protein expression once every 24 hours tocontrol when a particular physiological process is most activewith respect to the solar day. Transcription and translation ofcore clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2,PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythmgeneration, whereas delays imposed by post-translationalmodifications (PTMs) are important for determining the period(tau) of the rhythms (tau refers to the period of a rhythm and isthe length, in time, of one complete cycle). A diurnal rhythm issynchronized with the day/night cycle, while the ultradian andinfradian rhythms have a period shorter and longer than 24 hours,respectively. Disruptions in the circadian rhythms contribute tothe pathology of cardiovascular diseases, cancer, metabolicsyndromes and aging. A transcription/translation feedback loop(TTFL) forms the core of the molecular circadian clock mechanism.Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 orARNTL2/BMAL2, form the positive limb of the feedback loop, act inthe form of a heterodimer and activate the transcription of coreclock genes and clock-controlled genes (involved in key metabolicprocesses), harboring E-box elements (5'-CACGTG-3') within theirpromoters. The core clock genes: PER1/2/3 and CRY1/2 which aretranscriptional repressors form the negative limb of the feedbackloop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2heterodimer inhibiting its activity and thereby negativelyregulating their own expression. This heterodimer also activatesnuclear receptors NR1D1/2 and RORA/B/G, which form a secondfeedback loop and which activate and repress ARNTL/BMAL1transcription, respectively. The NPAS2-ARNTL/BMAL1 heterodimerpositively regulates the expression of MAOA, F7 and LDHA andmodulates the circadian rhythm of daytime contrast sensitivity byregulating the rhythmic expression of adenylate cyclase type 1(ADCY1) in the retina. NPAS2 plays an important role in sleephomeostasis and in maintaining circadian behaviors in normallight/dark and feeding conditions and in the effectivesynchronization of feeding behavior with scheduled foodavailability. Regulates the gene transcription of key metabolicpathways in the liver and is involved in DNA damage response byregulating several cell cycle and DNA repair genes.{ECO:0000269|PubMed:11441146, ECO:0000269|PubMed:11441147,ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:18439826,ECO:0000269|PubMed:18819933}. | Component of the CCR4-NOT complex which is one of themajor cellular mRNA deadenylases and is linked to various cellularprocesses including bulk mRNA degradation, miRNA-mediatedrepression, translational repression during translationalinitiation and general transcription regulation. Additionalcomplex functions may be a consequence of its influence on mRNAexpression. Is required for the association of CNOT10 with theCCR4-NOT complex. Seems not to be required for complex deadenylasefunction. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NPAS2 | chr2:101565942 | chr2:101879001 | ENST00000335681 | + | 7 | 21 | 82_152 | 199 | 825 | Domain | PAS 1 |
| Hgene | NPAS2 | chr2:101565942 | chr2:101879001 | ENST00000335681 | + | 7 | 21 | 9_59 | 199 | 825 | Domain | bHLH |
| Hgene | NPAS2 | chr2:101565942 | chr2:101879001 | ENST00000335681 | + | 7 | 21 | 1_61 | 199 | 825 | Region | Sufficient for heterodimer formation with ARNTL/BMAL1%2C E-box binding and for the effect of NADPH |
| Tgene | >CNOT11 | chr2:101565942 | chr2:101879001 | ENST00000289382 | + | 1 | 7 | 287_290 | 226 | 511 | Compositional bias | Note=Poly-Pro |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NPAS2 | chr2:101565942 | chr2:101879001 | ENST00000335681 | + | 7 | 21 | 237_307 | 199 | 825 | Domain | PAS 2 |
| Hgene | >NPAS2 | chr2:101565942 | chr2:101879001 | ENST00000335681 | + | 7 | 21 | 311_354 | 199 | 825 | Domain | Note=PAC |
| Tgene | CNOT11 | chr2:101565942 | chr2:101879001 | ENST00000289382 | + | 1 | 7 | 155_180 | 226 | 511 | Compositional bias | Note=Pro-rich |
| Tgene | CNOT11 | chr2:101565942 | chr2:101879001 | ENST00000289382 | + | 1 | 7 | 3_59 | 226 | 511 | Compositional bias | Note=Gly-rich |
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FusionGeneSequence for NPAS2_CNOT11 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NPAS2_ENST00000335681_chr2_101565942_+_CNOT11_ENST00000289382_chr2_101879001_+_484aa MDEDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLML EALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPK EFPTYEYIKFVGNFRSYNNERQSELPTQSKASFPSILSDPDPDSSNSGFDSSVASQITEALVSGPKPPIESHFRPEFIRPPPPLHICEDE LAWLNPTEPDHAIQWDKSMCVKNSTGVEIKRIMAKAFKSPLSSPQQTQLLGELEKDPKLVYHIGLTPAKLPDLVENNPLVAIEMLLKLMQ SSQITEYFSVLVNMDMSLHSMEVVNRLTTAVDLPPEFIHLYISNCISTCEQIKDKYMQNRLVRLVCVFLQSLIRNKIINVQDLFIEVQAF >In-frame_NPAS2_ENST00000542504_chr2_101565942_+_CNOT11_ENST00000289382_chr2_101879001_+_549aa MYAYGFVGRCAPFPAEEGRTFDLSEELGRSVTREGTGTTRLNSEPVPLLCLPLLNCSRKNCIENLMDEDEKDRAKRASRNKSEKKRRDQF NVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITP LLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNERQSEL PTQSKASFPSILSDPDPDSSNSGFDSSVASQITEALVSGPKPPIESHFRPEFIRPPPPLHICEDELAWLNPTEPDHAIQWDKSMCVKNST GVEIKRIMAKAFKSPLSSPQQTQLLGELEKDPKLVYHIGLTPAKLPDLVENNPLVAIEMLLKLMQSSQITEYFSVLVNMDMSLHSMEVVN RLTTAVDLPPEFIHLYISNCISTCEQIKDKYMQNRLVRLVCVFLQSLIRNKIINVQDLFIEVQAFCIEFSRIREAAGLFRLLKTLDTGET |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NPAS2_ENST00000335681_chr2_101565942_+_CNOT11_ENST00000289382_chr2_101879001_+_1452nt ATGGATGAAGATGAGAAAGACAGAGCCAAGAGAGCTTCTCGAAACAAGTCTGAGAAGAAGCGTCGGGACCAGTTCAATGTTCTCATCAAA GAGCTCAGTTCCATGCTCCCTGGCAACACGCGGAAAATGGACAAAACCACCGTGTTGGAAAAGGTCATCGGATTTTTGCAGAAACACAAT GAAGTCTCAGCGCAAACGGAAATCTGTGACATTCAGCAAGACTGGAAGCCTTCATTCCTCAGTAATGAAGAATTCACCCAGCTGATGTTG GAGGCATTAGATGGCTTCATTATCGCAGTGACAACAGACGGCAGCATCATCTATGTCTCTGACAGTATCACGCCTCTCCTTGGGCATTTA CCGTCGGATGTCATGGATCAGAATTTGTTAAATTTCCTCCCAGAACAAGAACATTCAGAAGTTTATAAAATCCTTTCTTCCCATATGCTT GTGACGGATTCCCCCTCCCCAGAATACTTAAAATCTGACAGCGATTTAGAGTTTTATTGCCATCTTCTCAGAGGCAGCTTGAACCCAAAG GAATTTCCAACTTATGAATACATAAAATTTGTAGGAAATTTTCGCTCTTACAACAATGAACGCCAATCTGAATTGCCAACGCAAAGCAAA GCGAGCTTCCCCAGTATTCTCAGTGACCCAGACCCGGATTCTTCTAATTCTGGATTTGACAGCTCAGTTGCCTCTCAGATCACAGAAGCT TTAGTCAGCGGACCAAAGCCACCTATTGAAAGCCATTTTCGACCAGAGTTTATTCGTCCACCGCCTCCACTCCACATTTGTGAGGATGAA CTTGCTTGGCTAAACCCCACGGAGCCTGACCACGCGATCCAGTGGGATAAATCGATGTGTGTTAAGAATAGCACTGGTGTGGAGATCAAA CGAATAATGGCCAAAGCCTTCAAAAGCCCCTTATCCTCTCCCCAACAAACACAGCTACTTGGTGAGTTGGAAAAAGACCCCAAACTTGTC TACCATATTGGCCTCACCCCAGCCAAACTTCCTGACCTTGTGGAAAACAACCCTTTAGTCGCTATAGAAATGTTGCTGAAATTAATGCAG TCAAGCCAGATCACTGAGTATTTCTCTGTCCTGGTCAATATGGACATGTCTTTACATTCAATGGAAGTTGTAAATCGACTAACTACAGCT GTTGATCTACCTCCTGAATTTATTCACCTTTATATATCAAATTGCATCTCTACTTGTGAACAGATTAAGGATAAATATATGCAGAATCGG TTGGTGCGTCTTGTGTGTGTGTTTCTCCAATCCTTGATCCGTAACAAAATTATTAATGTACAGGATTTGTTTATAGAAGTGCAGGCATTC TGTATTGAATTCAGTAGGATACGAGAAGCTGCTGGTCTTTTCCGGTTGTTGAAGACATTGGATACTGGGGAAACACCTTCTGAGACCAAA >In-frame_NPAS2_ENST00000542504_chr2_101565942_+_CNOT11_ENST00000289382_chr2_101879001_+_1647nt ATGTATGCGTATGGTTTTGTTGGGAGATGTGCCCCTTTCCCAGCCGAGGAGGGACGCACCTTTGACCTTTCTGAAGAGCTGGGCAGGTCG GTAACCAGGGAAGGGACAGGCACCACCCGGCTAAATTCAGAACCAGTCCCGCTCCTCTGCTTGCCACTCCTTAATTGCTCAAGGAAAAAC TGCATAGAAAATCTAATGGATGAAGATGAGAAAGACAGAGCCAAGAGAGCTTCTCGAAACAAGTCTGAGAAGAAGCGTCGGGACCAGTTC AATGTTCTCATCAAAGAGCTCAGTTCCATGCTCCCTGGCAACACGCGGAAAATGGACAAAACCACCGTGTTGGAAAAGGTCATCGGATTT TTGCAGAAACACAATGAAGTCTCAGCGCAAACGGAAATCTGTGACATTCAGCAAGACTGGAAGCCTTCATTCCTCAGTAATGAAGAATTC ACCCAGCTGATGTTGGAGGCATTAGATGGCTTCATTATCGCAGTGACAACAGACGGCAGCATCATCTATGTCTCTGACAGTATCACGCCT CTCCTTGGGCATTTACCGTCGGATGTCATGGATCAGAATTTGTTAAATTTCCTCCCAGAACAAGAACATTCAGAAGTTTATAAAATCCTT TCTTCCCATATGCTTGTGACGGATTCCCCCTCCCCAGAATACTTAAAATCTGACAGCGATTTAGAGTTTTATTGCCATCTTCTCAGAGGC AGCTTGAACCCAAAGGAATTTCCAACTTATGAATACATAAAATTTGTAGGAAATTTTCGCTCTTACAACAATGAACGCCAATCTGAATTG CCAACGCAAAGCAAAGCGAGCTTCCCCAGTATTCTCAGTGACCCAGACCCGGATTCTTCTAATTCTGGATTTGACAGCTCAGTTGCCTCT CAGATCACAGAAGCTTTAGTCAGCGGACCAAAGCCACCTATTGAAAGCCATTTTCGACCAGAGTTTATTCGTCCACCGCCTCCACTCCAC ATTTGTGAGGATGAACTTGCTTGGCTAAACCCCACGGAGCCTGACCACGCGATCCAGTGGGATAAATCGATGTGTGTTAAGAATAGCACT GGTGTGGAGATCAAACGAATAATGGCCAAAGCCTTCAAAAGCCCCTTATCCTCTCCCCAACAAACACAGCTACTTGGTGAGTTGGAAAAA GACCCCAAACTTGTCTACCATATTGGCCTCACCCCAGCCAAACTTCCTGACCTTGTGGAAAACAACCCTTTAGTCGCTATAGAAATGTTG CTGAAATTAATGCAGTCAAGCCAGATCACTGAGTATTTCTCTGTCCTGGTCAATATGGACATGTCTTTACATTCAATGGAAGTTGTAAAT CGACTAACTACAGCTGTTGATCTACCTCCTGAATTTATTCACCTTTATATATCAAATTGCATCTCTACTTGTGAACAGATTAAGGATAAA TATATGCAGAATCGGTTGGTGCGTCTTGTGTGTGTGTTTCTCCAATCCTTGATCCGTAACAAAATTATTAATGTACAGGATTTGTTTATA GAAGTGCAGGCATTCTGTATTGAATTCAGTAGGATACGAGAAGCTGCTGGTCTTTTCCGGTTGTTGAAGACATTGGATACTGGGGAAACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NPAS2_ENST00000335681_chr2_101565942_+_CNOT11_ENST00000289382_chr2_101879001_+_2640nt TTTGCCGCGCGAGCAGCCGGCCTCTCGCAGGAGCCGAGGGACCCGCGCGGCTGCGGCCCAGGAGCGGCGGCCGCGGAGCCCGGAGACCCG CAGCCGCGGCGGCGGCGGCGGCGGCGGCAGCAGCTAGAGCAGCGCCTCCCGCCGCCGCCCGGGAGGAGCTCGCCGCGCCCGCTCGCCGCC TCGTCTCCCAGCGGCGGCGGGAGGCGCGTCTCCCCGGCCCAGTCCGCGCCCGGCCCCGCGGGGCCGCTCCGGCCCGCTCCGAGGAAAAAC TGCATAGAAAATCTAATGGATGAAGATGAGAAAGACAGAGCCAAGAGAGCTTCTCGAAACAAGTCTGAGAAGAAGCGTCGGGACCAGTTC AATGTTCTCATCAAAGAGCTCAGTTCCATGCTCCCTGGCAACACGCGGAAAATGGACAAAACCACCGTGTTGGAAAAGGTCATCGGATTT TTGCAGAAACACAATGAAGTCTCAGCGCAAACGGAAATCTGTGACATTCAGCAAGACTGGAAGCCTTCATTCCTCAGTAATGAAGAATTC ACCCAGCTGATGTTGGAGGCATTAGATGGCTTCATTATCGCAGTGACAACAGACGGCAGCATCATCTATGTCTCTGACAGTATCACGCCT CTCCTTGGGCATTTACCGTCGGATGTCATGGATCAGAATTTGTTAAATTTCCTCCCAGAACAAGAACATTCAGAAGTTTATAAAATCCTT TCTTCCCATATGCTTGTGACGGATTCCCCCTCCCCAGAATACTTAAAATCTGACAGCGATTTAGAGTTTTATTGCCATCTTCTCAGAGGC AGCTTGAACCCAAAGGAATTTCCAACTTATGAATACATAAAATTTGTAGGAAATTTTCGCTCTTACAACAATGAACGCCAATCTGAATTG CCAACGCAAAGCAAAGCGAGCTTCCCCAGTATTCTCAGTGACCCAGACCCGGATTCTTCTAATTCTGGATTTGACAGCTCAGTTGCCTCT CAGATCACAGAAGCTTTAGTCAGCGGACCAAAGCCACCTATTGAAAGCCATTTTCGACCAGAGTTTATTCGTCCACCGCCTCCACTCCAC ATTTGTGAGGATGAACTTGCTTGGCTAAACCCCACGGAGCCTGACCACGCGATCCAGTGGGATAAATCGATGTGTGTTAAGAATAGCACT GGTGTGGAGATCAAACGAATAATGGCCAAAGCCTTCAAAAGCCCCTTATCCTCTCCCCAACAAACACAGCTACTTGGTGAGTTGGAAAAA GACCCCAAACTTGTCTACCATATTGGCCTCACCCCAGCCAAACTTCCTGACCTTGTGGAAAACAACCCTTTAGTCGCTATAGAAATGTTG CTGAAATTAATGCAGTCAAGCCAGATCACTGAGTATTTCTCTGTCCTGGTCAATATGGACATGTCTTTACATTCAATGGAAGTTGTAAAT CGACTAACTACAGCTGTTGATCTACCTCCTGAATTTATTCACCTTTATATATCAAATTGCATCTCTACTTGTGAACAGATTAAGGATAAA TATATGCAGAATCGGTTGGTGCGTCTTGTGTGTGTGTTTCTCCAATCCTTGATCCGTAACAAAATTATTAATGTACAGGATTTGTTTATA GAAGTGCAGGCATTCTGTATTGAATTCAGTAGGATACGAGAAGCTGCTGGTCTTTTCCGGTTGTTGAAGACATTGGATACTGGGGAAACA CCTTCTGAGACCAAAATGTCAAAATAATACCTCATCAGAACCATCCCATCCATTCACTGTTCAGCTGTACTGTGATTTAGTTTTTACACC GTTAAAACCCTGAGTGGATTGCTTGGTTTAATGCATATAAACAGTACTTTATCTACTTAAAGCAAAGTTTTGCTTTCTTGAATGACTTTT TCTGTGAGATGAATTTTTGATAAGAACTAGGGAAAACATGTCTTTTAGGTGTCTTGCTGATGACTATCCATAGGAGGAATGGCTATCCCA AAAAAAGTTCCGCAAAAAAGTAGATGAGTTTCTTTTTTTTTTAAGCACTAAAGAACAAAATGCATTTTTCATTAATACAGGCTTCTGATG AACCAGGAATCCTGTTTTCGTAAAGTTCCAATGTTGATGAGAGTAAATTCTTAAGCATTTGTCCTAGAGGTGAAAGCAGCTGAATGTTTC TGAACCATCAAGAGGCAAACAAACAGGAGTTTGTTTCTTGAACCTGCTTATGCACACAGCTCTTAACTCCTCATGAGGCACACAGCTCTT AACTCCTGATGAACCAAGGATTTACTCATAACTTTCTCCTTGTCATGGAGGCTTAATAGACAACAGAATAAATGCATTTCTTGGGCCTCT TATAAACTTGGGAATTCTTAGAAAGCTGCTTCTATTACCAGGCTGTAATAGCTGGTATAGTTTTTTTTTTTTCTCTTAAGATGTTCTGTT ATTAGTCTGAGACAGCCATTTTTTTGTTTTAAGGAAAAATATCAGTCAGTGCTCCGGGAGGTAATTTCCTGTGGGGTCTGCACCCTCCTG TCTGGGTGGTGGATGTGGGTTTGAGAAGTAGGAGAGCAGGGTGGTACCGTGTGGGCTCTTACCCTTTATGTGATTTTGGACAACAGTGCC >In-frame_NPAS2_ENST00000542504_chr2_101565942_+_CNOT11_ENST00000289382_chr2_101879001_+_2552nt GGATGTATGCGTATGGTTTTGTTGGGAGATGTGCCCCTTTCCCAGCCGAGGAGGGACGCACCTTTGACCTTTCTGAAGAGCTGGGCAGGT CGGTAACCAGGGAAGGGACAGGCACCACCCGGCTAAATTCAGAACCAGTCCCGCTCCTCTGCTTGCCACTCCTTAATTGCTCAAGGAAAA ACTGCATAGAAAATCTAATGGATGAAGATGAGAAAGACAGAGCCAAGAGAGCTTCTCGAAACAAGTCTGAGAAGAAGCGTCGGGACCAGT TCAATGTTCTCATCAAAGAGCTCAGTTCCATGCTCCCTGGCAACACGCGGAAAATGGACAAAACCACCGTGTTGGAAAAGGTCATCGGAT TTTTGCAGAAACACAATGAAGTCTCAGCGCAAACGGAAATCTGTGACATTCAGCAAGACTGGAAGCCTTCATTCCTCAGTAATGAAGAAT TCACCCAGCTGATGTTGGAGGCATTAGATGGCTTCATTATCGCAGTGACAACAGACGGCAGCATCATCTATGTCTCTGACAGTATCACGC CTCTCCTTGGGCATTTACCGTCGGATGTCATGGATCAGAATTTGTTAAATTTCCTCCCAGAACAAGAACATTCAGAAGTTTATAAAATCC TTTCTTCCCATATGCTTGTGACGGATTCCCCCTCCCCAGAATACTTAAAATCTGACAGCGATTTAGAGTTTTATTGCCATCTTCTCAGAG GCAGCTTGAACCCAAAGGAATTTCCAACTTATGAATACATAAAATTTGTAGGAAATTTTCGCTCTTACAACAATGAACGCCAATCTGAAT TGCCAACGCAAAGCAAAGCGAGCTTCCCCAGTATTCTCAGTGACCCAGACCCGGATTCTTCTAATTCTGGATTTGACAGCTCAGTTGCCT CTCAGATCACAGAAGCTTTAGTCAGCGGACCAAAGCCACCTATTGAAAGCCATTTTCGACCAGAGTTTATTCGTCCACCGCCTCCACTCC ACATTTGTGAGGATGAACTTGCTTGGCTAAACCCCACGGAGCCTGACCACGCGATCCAGTGGGATAAATCGATGTGTGTTAAGAATAGCA CTGGTGTGGAGATCAAACGAATAATGGCCAAAGCCTTCAAAAGCCCCTTATCCTCTCCCCAACAAACACAGCTACTTGGTGAGTTGGAAA AAGACCCCAAACTTGTCTACCATATTGGCCTCACCCCAGCCAAACTTCCTGACCTTGTGGAAAACAACCCTTTAGTCGCTATAGAAATGT TGCTGAAATTAATGCAGTCAAGCCAGATCACTGAGTATTTCTCTGTCCTGGTCAATATGGACATGTCTTTACATTCAATGGAAGTTGTAA ATCGACTAACTACAGCTGTTGATCTACCTCCTGAATTTATTCACCTTTATATATCAAATTGCATCTCTACTTGTGAACAGATTAAGGATA AATATATGCAGAATCGGTTGGTGCGTCTTGTGTGTGTGTTTCTCCAATCCTTGATCCGTAACAAAATTATTAATGTACAGGATTTGTTTA TAGAAGTGCAGGCATTCTGTATTGAATTCAGTAGGATACGAGAAGCTGCTGGTCTTTTCCGGTTGTTGAAGACATTGGATACTGGGGAAA CACCTTCTGAGACCAAAATGTCAAAATAATACCTCATCAGAACCATCCCATCCATTCACTGTTCAGCTGTACTGTGATTTAGTTTTTACA CCGTTAAAACCCTGAGTGGATTGCTTGGTTTAATGCATATAAACAGTACTTTATCTACTTAAAGCAAAGTTTTGCTTTCTTGAATGACTT TTTCTGTGAGATGAATTTTTGATAAGAACTAGGGAAAACATGTCTTTTAGGTGTCTTGCTGATGACTATCCATAGGAGGAATGGCTATCC CAAAAAAAGTTCCGCAAAAAAGTAGATGAGTTTCTTTTTTTTTTAAGCACTAAAGAACAAAATGCATTTTTCATTAATACAGGCTTCTGA TGAACCAGGAATCCTGTTTTCGTAAAGTTCCAATGTTGATGAGAGTAAATTCTTAAGCATTTGTCCTAGAGGTGAAAGCAGCTGAATGTT TCTGAACCATCAAGAGGCAAACAAACAGGAGTTTGTTTCTTGAACCTGCTTATGCACACAGCTCTTAACTCCTCATGAGGCACACAGCTC TTAACTCCTGATGAACCAAGGATTTACTCATAACTTTCTCCTTGTCATGGAGGCTTAATAGACAACAGAATAAATGCATTTCTTGGGCCT CTTATAAACTTGGGAATTCTTAGAAAGCTGCTTCTATTACCAGGCTGTAATAGCTGGTATAGTTTTTTTTTTTTCTCTTAAGATGTTCTG TTATTAGTCTGAGACAGCCATTTTTTTGTTTTAAGGAAAAATATCAGTCAGTGCTCCGGGAGGTAATTTCCTGTGGGGTCTGCACCCTCC TGTCTGGGTGGTGGATGTGGGTTTGAGAAGTAGGAGAGCAGGGTGGTACCGTGTGGGCTCTTACCCTTTATGTGATTTTGGACAACAGTG |
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FusionGenePPI for NPAS2_CNOT11 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NPAS2 | EP300, NCOA3, KAT2B, CREBBP, RXRA, RARA, ARNTL, HSP90AA1, HESX1, RHOXF1, ZSCAN1, TRAF4, RPL6, ARNT2, ARNTL2, CRX, EFS, HGS, RASSF7, SHMT2, CLOCK, CRY1, CSNK2B, DEC1, RORC, CRY2 | CNOT11 | ELAVL1, NLK, CT55, MMP7, CAPZA2, CNOT7, BTRC, MED4, OFD1, CEP120, CNTROB, XPO1, CNOT2, CNOT1, RC3H1, CNOT6, CNOT6L, CNOT10, NANOS2, TNKS1BP1, CNOT3, RIBC1, CNOT8, RAVER1, TOB1, GPBP1L1, BTG3, RQCD1, TEX13A, GADD45B, GGNBP2, FHL2, TBC1D10A, EDRF1, IZUMO1, FBXW11, MAP4K4, GLA, NFKB1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NPAS2_CNOT11 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NPAS2_CNOT11 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NPAS2 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
| Hgene | NPAS2 | C0085159 | Seasonal Affective Disorder | 4 | PSYGENET |
| Hgene | NPAS2 | C0011581 | Depressive disorder | 2 | PSYGENET |
| Hgene | NPAS2 | C0004352 | Autistic Disorder | 1 | CTD_human |
| Hgene | NPAS2 | C0011570 | Mental Depression | 1 | PSYGENET |
| Hgene | NPAS2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | NPAS2 | C0036337 | Schizoaffective Disorder | 1 | PSYGENET |
| Hgene | NPAS2 | C0036341 | Schizophrenia | 1 | PSYGENET |
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