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Fusion gene ID: 24657 |
FusionGeneSummary for NOV_ENPP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NOV_ENPP2 | Fusion gene ID: 24657 | Hgene | Tgene | Gene symbol | NOV | ENPP2 | Gene ID | 6134 | 5168 |
| Gene name | ribosomal protein L10 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | |
| Synonyms | AUTSX5|DXS648|DXS648E|L10|MRXS35|NOV|QM | ATX|ATX-X|AUTOTAXIN|LysoPLD|NPP2|PD-IALPHA|PDNP2 | |
| Cytomap | Xq28 | 8q24.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 60S ribosomal protein L10Wilms tumor-related proteinlaminin receptor homologlarge ribosomal subunit protein uL16tumor suppressor QM | ectonucleotide pyrophosphatase/phosphodiesterase family member 2E-NPP 2autotaxin-textracellular lysophospholipase Dphosphodiesterase I/nucleotide pyrophosphatase 2plasma lysophospholipase D | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P48745 | Q13822 | |
| Ensembl transtripts involved in fusion gene | ENST00000259526, | ENST00000259486, ENST00000427067, ENST00000522167, ENST00000522826, ENST00000075322, ENST00000518109, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 6 X 3=108 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NOV [Title/Abstract] AND ENPP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ENPP2 | GO:0009395 | phospholipid catabolic process | 15280042 |
| Tgene | ENPP2 | GO:0030334 | regulation of cell migration | 1733949 |
| Tgene | ENPP2 | GO:0034638 | phosphatidylcholine catabolic process | 21240271 |
| Tgene | ENPP2 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 18054784 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-JY-A6FD-01A | NOV | chr8 | 120431585 | + | ENPP2 | chr8 | 120606100 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000259526 | ENST00000259486 | NOV | chr8 | 120431585 | + | ENPP2 | chr8 | 120606100 | - |
| In-frame | ENST00000259526 | ENST00000427067 | NOV | chr8 | 120431585 | + | ENPP2 | chr8 | 120606100 | - |
| 5CDS-intron | ENST00000259526 | ENST00000522167 | NOV | chr8 | 120431585 | + | ENPP2 | chr8 | 120606100 | - |
| 5CDS-intron | ENST00000259526 | ENST00000522826 | NOV | chr8 | 120431585 | + | ENPP2 | chr8 | 120606100 | - |
| 5CDS-intron | ENST00000259526 | ENST00000075322 | NOV | chr8 | 120431585 | + | ENPP2 | chr8 | 120606100 | - |
| 5CDS-intron | ENST00000259526 | ENST00000518109 | NOV | chr8 | 120431585 | + | ENPP2 | chr8 | 120606100 | - |
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FusionProtFeatures for NOV_ENPP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NOV | ENPP2 |