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Fusion gene ID: 24627 |
FusionGeneSummary for NOTCH1_SDCCAG3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NOTCH1_SDCCAG3 | Fusion gene ID: 24627 | Hgene | Tgene | Gene symbol | NOTCH1 | SDCCAG3 | Gene ID | 4851 |
| Gene name | notch 1 | ||
| Synonyms | AOS5|AOVD1|TAN1|hN1 | ||
| Cytomap | 9q34.3 | ||
| Type of gene | protein-coding | ||
| Description | neurogenic locus notch homolog protein 1Notch homolog 1, translocation-associatedtranslocation-associated notch protein TAN-1 | ||
| Modification date | 20180527 | ||
| UniProtAcc | P46531 | Q96C92 | |
| Ensembl transtripts involved in fusion gene | ENST00000277541, ENST00000491649, | ENST00000357365, ENST00000298537, ENST00000371725, ENST00000461693, | |
| Fusion gene scores | * DoF score | 11 X 9 X 10=990 | 3 X 3 X 3=27 |
| # samples | 12 | 4 | |
| ** MAII score | log2(12/990*10)=-3.04439411935845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NOTCH1 [Title/Abstract] AND SDCCAG3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NOTCH1 | GO:0007050 | cell cycle arrest | 11306509 |
| Hgene | NOTCH1 | GO:0007219 | Notch signaling pathway | 11306509 |
| Hgene | NOTCH1 | GO:0008284 | positive regulation of cell proliferation | 17849174 |
| Hgene | NOTCH1 | GO:0008285 | negative regulation of cell proliferation | 11306509|20616313 |
| Hgene | NOTCH1 | GO:0010629 | negative regulation of gene expression | 11306509 |
| Hgene | NOTCH1 | GO:0010812 | negative regulation of cell-substrate adhesion | 16501043 |
| Hgene | NOTCH1 | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 20616313 |
| Hgene | NOTCH1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20616313 |
| Hgene | NOTCH1 | GO:0045967 | negative regulation of growth rate | 11306509 |
| Hgene | NOTCH1 | GO:0046579 | positive regulation of Ras protein signal transduction | 11306509 |
| Hgene | NOTCH1 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 11306509 |
| Hgene | NOTCH1 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus | 20613903 |
| Hgene | NOTCH1 | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis | 20616313 |
| Hgene | NOTCH1 | GO:2001027 | negative regulation of endothelial cell chemotaxis | 20616313 |