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Fusion gene ID: 2462

FusionGeneSummary for ARHGAP42_YAP1

Fusion gene summary

Fusion gene information	Fusion gene name: ARHGAP42_YAP1
	Fusion gene ID: 2462
		Hgene	Tgene
	Gene symbol	ARHGAP42	YAP1
	Gene ID	143872	10413
	Gene name	Rho GTPase activating protein 42	Yes associated protein 1
	Synonyms	AD031\|GRAF3\|TMEM133	COB1\|YAP\|YAP2\|YAP65\|YKI
	Cytomap	11q22.1	11q22.1
	Type of gene	protein-coding	protein-coding
	Description	rho GTPase-activating protein 42rho-type GTPase-activating protein 42transmembrane protein 133	transcriptional coactivator YAP165 kDa Yes-associated proteinprotein yorkie homologyes-associated protein 1yes-associated protein 2yes-associated protein YAP65 homologyorkie homolog
	Modification date	20180523	20180527
	UniProtAcc	A6NI28	P46937
	Ensembl transtripts involved in fusion gene	ENST00000524892, ENST00000298815, ENST00000534060,	ENST00000526343, ENST00000282441, ENST00000537274, ENST00000345877, ENST00000531439, ENST00000524575, ENST00000528834,
Fusion gene scores	* DoF score	7 X 4 X 6=168	13 X 7 X 11=1001
	# samples	7	13
	** MAII score	log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/1001*10)=-2.94485844580754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ARHGAP42 [Title/Abstract] AND YAP1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ARHGAP42	GO:0090630	activation of GTPase activity	24335996
Tgene	YAP1	GO:0006974	cellular response to DNA damage stimulus	18280240
Tgene	YAP1	GO:0008283	cell proliferation	17974916
Tgene	YAP1	GO:0032570	response to progesterone	16772533
Tgene	YAP1	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	16772533
Tgene	YAP1	GO:0045893	positive regulation of transcription, DNA-templated	20368466
Tgene	YAP1	GO:0045944	positive regulation of transcription by RNA polymerase II	25796446
Tgene	YAP1	GO:0050767	regulation of neurogenesis	25433207
Tgene	YAP1	GO:0050847	progesterone receptor signaling pathway	16772533
Tgene	YAP1	GO:0060242	contact inhibition	17974916
Tgene	YAP1	GO:0065003	protein-containing complex assembly	20368466
Tgene	YAP1	GO:0071480	cellular response to gamma radiation	18280240
Tgene	YAP1	GO:0072091	regulation of stem cell proliferation	25433207

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	HNSC	TCGA-CV-7235-01A	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000524892	ENST00000526343	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
In-frame	ENST00000524892	ENST00000282441	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
In-frame	ENST00000524892	ENST00000537274	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
In-frame	ENST00000524892	ENST00000345877	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
In-frame	ENST00000524892	ENST00000531439	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
In-frame	ENST00000524892	ENST00000524575	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
5CDS-intron	ENST00000524892	ENST00000528834	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
In-frame	ENST00000298815	ENST00000526343	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
In-frame	ENST00000298815	ENST00000282441	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
In-frame	ENST00000298815	ENST00000537274	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
In-frame	ENST00000298815	ENST00000345877	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
In-frame	ENST00000298815	ENST00000531439	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
In-frame	ENST00000298815	ENST00000524575	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
5CDS-intron	ENST00000298815	ENST00000528834	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
intron-3CDS	ENST00000534060	ENST00000526343	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
intron-3CDS	ENST00000534060	ENST00000282441	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
intron-3CDS	ENST00000534060	ENST00000537274	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
intron-3CDS	ENST00000534060	ENST00000345877	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
intron-3CDS	ENST00000534060	ENST00000531439	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
intron-3CDS	ENST00000534060	ENST00000524575	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+
intron-intron	ENST00000534060	ENST00000528834	ARHGAP42	chr11	100558563	+	YAP1	chr11	102076624	+

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FusionProtFeatures for ARHGAP42_YAP1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARHGAP42 A6NI28	YAP1 P46937

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Fusion gene ID: 2462

FusionGeneSummary for ARHGAP42_YAP1

FusionProtFeatures for ARHGAP42_YAP1