	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 24602

FusionGeneSummary for NOS1AP_ATF6

Fusion gene summary

Fusion gene information	Fusion gene name: NOS1AP_ATF6
	Fusion gene ID: 24602
		Hgene	Tgene
	Gene symbol	NOS1AP	ATF6
	Gene ID	9722	22926
	Gene name	nitric oxide synthase 1 adaptor protein	activating transcription factor 6
	Synonyms	6330408P19Rik\|CAPON	ACHM7\|ATF6A
	Cytomap	1q23.3	1q23.3
	Type of gene	protein-coding	protein-coding
	Description	carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase proteinC-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON)C-terminal PDZ ligand of neuronal nitric oxide synthase proteinligand of neuronal nitric oxide synthase with car	cyclic AMP-dependent transcription factor ATF-6 alphacAMP-dependent transcription factor ATF-6 alpha
	Modification date	20180519	20180522
	UniProtAcc	O75052	P18850
	Ensembl transtripts involved in fusion gene	ENST00000530878, ENST00000361897, ENST00000493151, ENST00000454693,	ENST00000367942, ENST00000476437,
Fusion gene scores	* DoF score	12 X 8 X 7=672	8 X 7 X 7=392
	# samples	14	11
	** MAII score	log2(14/672*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/392*10)=-1.83335013059055 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NOS1AP [Title/Abstract] AND ATF6 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Transcription factor involved fusion gene, inframe and retained DNA-binding domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ATF6	GO:0043065	positive regulation of apoptotic process	14752510
Tgene	ATF6	GO:0045944	positive regulation of transcription by RNA polymerase II	14973138
Tgene	ATF6	GO:1903893	positive regulation of ATF6-mediated unfolded protein response	9837962
Tgene	ATF6	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	11163209\|11256944\|16469704

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LUAD	TCGA-NJ-A4YF-01A	NOS1AP	chr1	162040072	+	ATF6	chr1	161928236	+
TCGA	RV	UCEC	TCGA-FI-A3PX-01A	NOS1AP	chr1	162257226	+	ATF6	chr1	161789423	+
TCGA	RV	UCEC	TCGA-DF-A2KR-01A	NOS1AP	chr1	162040072	+	ATF6	chr1	161928236	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000530878	ENST00000367942	NOS1AP	chr1	162040072	+	ATF6	chr1	161928236	+
5CDS-intron	ENST00000530878	ENST00000476437	NOS1AP	chr1	162040072	+	ATF6	chr1	161928236	+
Frame-shift	ENST00000361897	ENST00000367942	NOS1AP	chr1	162040072	+	ATF6	chr1	161928236	+
5CDS-intron	ENST00000361897	ENST00000476437	NOS1AP	chr1	162040072	+	ATF6	chr1	161928236	+
intron-3CDS	ENST00000493151	ENST00000367942	NOS1AP	chr1	162040072	+	ATF6	chr1	161928236	+
intron-intron	ENST00000493151	ENST00000476437	NOS1AP	chr1	162040072	+	ATF6	chr1	161928236	+
intron-3CDS	ENST00000454693	ENST00000367942	NOS1AP	chr1	162040072	+	ATF6	chr1	161928236	+
intron-intron	ENST00000454693	ENST00000476437	NOS1AP	chr1	162040072	+	ATF6	chr1	161928236	+
In-frame	ENST00000530878	ENST00000367942	NOS1AP	chr1	162257226	+	ATF6	chr1	161789423	+
5CDS-intron	ENST00000530878	ENST00000476437	NOS1AP	chr1	162257226	+	ATF6	chr1	161789423	+
In-frame	ENST00000361897	ENST00000367942	NOS1AP	chr1	162257226	+	ATF6	chr1	161789423	+
5CDS-intron	ENST00000361897	ENST00000476437	NOS1AP	chr1	162257226	+	ATF6	chr1	161789423	+
intron-3CDS	ENST00000493151	ENST00000367942	NOS1AP	chr1	162257226	+	ATF6	chr1	161789423	+
intron-intron	ENST00000493151	ENST00000476437	NOS1AP	chr1	162257226	+	ATF6	chr1	161789423	+
intron-3CDS	ENST00000454693	ENST00000367942	NOS1AP	chr1	162257226	+	ATF6	chr1	161789423	+
intron-intron	ENST00000454693	ENST00000476437	NOS1AP	chr1	162257226	+	ATF6	chr1	161789423	+

Top

FusionProtFeatures for NOS1AP_ATF6

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NOS1AP O75052	ATF6 P18850

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 24602

FusionGeneSummary for NOS1AP_ATF6

FusionProtFeatures for NOS1AP_ATF6