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Fusion gene ID: 24593 |
FusionGeneSummary for NOP2_PIANP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NOP2_PIANP | Fusion gene ID: 24593 | Hgene | Tgene | Gene symbol | NOP2 | PIANP | Gene ID | 4839 | 196500 |
| Gene name | NOP2 nucleolar protein | PILR alpha associated neural protein | |
| Synonyms | NOL1|NOP120|NSUN1|p120 | C12orf53|LEDA1|PANP|leda-1 | |
| Cytomap | 12p13.31 | 12p13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable 28S rRNA (cytosine(4447)-C(5))-methyltransferaseNOL1/NOP2/Sun domain family, member 1NOP2 nucleolar protein homolognucleolar protein 1, 120kDanucleolar protein 2 homologproliferating-cell nucleolar antigen p120proliferation-associated nucle | PILR alpha-associated neural proteinPILR-associating neural proteinliver endothelial differentiation-associated protein-1paired immunoglobin-like type 2 receptor-associating neural protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P46087 | Q8IYJ0 | |
| Ensembl transtripts involved in fusion gene | ENST00000537442, ENST00000382421, ENST00000545200, ENST00000399466, ENST00000322166, ENST00000541778, ENST00000542015, ENST00000545915, ENST00000540228, | ENST00000540656, ENST00000320591, ENST00000534837, | |
| Fusion gene scores | * DoF score | 3 X 4 X 2=24 | 2 X 1 X 2=4 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: NOP2 [Title/Abstract] AND PIANP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NOP2 | GO:0008284 | positive regulation of cell proliferation | 1394192 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-BC-A8YO-01A | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000537442 | ENST00000540656 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000537442 | ENST00000320591 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000537442 | ENST00000534837 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000382421 | ENST00000540656 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000382421 | ENST00000320591 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000382421 | ENST00000534837 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000545200 | ENST00000540656 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000545200 | ENST00000320591 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000545200 | ENST00000534837 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000399466 | ENST00000540656 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000399466 | ENST00000320591 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000399466 | ENST00000534837 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000322166 | ENST00000540656 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000322166 | ENST00000320591 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000322166 | ENST00000534837 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000541778 | ENST00000540656 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000541778 | ENST00000320591 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000541778 | ENST00000534837 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5UTR-5UTR | ENST00000542015 | ENST00000540656 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5UTR-5UTR | ENST00000542015 | ENST00000320591 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5UTR-5UTR | ENST00000542015 | ENST00000534837 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000545915 | ENST00000540656 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000545915 | ENST00000320591 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000545915 | ENST00000534837 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000540228 | ENST00000540656 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000540228 | ENST00000320591 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
| 5CDS-5UTR | ENST00000540228 | ENST00000534837 | NOP2 | chr12 | 6676982 | - | PIANP | chr12 | 6807270 | - |
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FusionProtFeatures for NOP2_PIANP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NOP2 | PIANP |