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Fusion gene ID: 24488

FusionGeneSummary for NME2_CCL4L2

Fusion gene summary

Fusion gene information	Fusion gene name: NME2_CCL4L2
	Fusion gene ID: 24488
		Hgene	Tgene
	Gene symbol	NME2	CCL4L2
	Gene ID	4831	9560
	Gene name	NME/NM23 nucleoside diphosphate kinase 2	C-C motif chemokine ligand 4 like 2
	Synonyms	NDKB\|NDPK-B\|NDPKB\|NM23-H2\|NM23B\|PUF	AT744.2\|CCL4L\|SCYA4L\|SCYQ4L2
	Cytomap	17q21.33	17q12
	Type of gene	protein-coding	protein-coding
	Description	nucleoside diphosphate kinase BHEL-S-155anNDP kinase Bc-myc purine-binding transcription factor PUFc-myc transcription factorepididymis secretory sperm binding protein Li 155anhistidine protein kinase NDKBnon-metastatic cells 2, protein (NM23) expr	C-C motif chemokine 4-likeMIP-1-betachemokine (C-C motif) ligand 4-like 2macrophage inflammatory protein 1-betamacrophage inflammatory protein-1b2monocyte adherence-induced protein 5-alphasmall inducible cytokine A4-like
	Modification date	20180523	20180519
	UniProtAcc	P22392	Q8NHW4
	Ensembl transtripts involved in fusion gene	ENST00000393193, ENST00000376392, ENST00000555572,	ENST00000394465, ENST00000378342, ENST00000394463, ENST00000339270, ENST00000482104,
Fusion gene scores	* DoF score	5 X 5 X 4=100	2 X 1 X 2=4
	# samples	5	2
	** MAII score	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/4*10)=2.32192809488736
Context	PubMed: NME2 [Title/Abstract] AND CCL4L2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NME2	GO:0007229	integrin-mediated signaling pathway	11919189
Hgene	NME2	GO:0009142	nucleoside triphosphate biosynthetic process	1851158
Hgene	NME2	GO:0045944	positive regulation of transcription by RNA polymerase II	15703214

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	LUAD	TCGA-97-7554-01A	NME2	chr17	49245704	+	CCL4L2	chr17	34539178	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000393193	ENST00000394465	NME2	chr17	49245704	+	CCL4L2	chr17	34539178	+
5CDS-intron	ENST00000393193	ENST00000378342	NME2	chr17	49245704	+	CCL4L2	chr17	34539178	+
5CDS-intron	ENST00000393193	ENST00000394463	NME2	chr17	49245704	+	CCL4L2	chr17	34539178	+
5CDS-intron	ENST00000393193	ENST00000339270	NME2	chr17	49245704	+	CCL4L2	chr17	34539178	+
5CDS-intron	ENST00000393193	ENST00000482104	NME2	chr17	49245704	+	CCL4L2	chr17	34539178	+
5CDS-intron	ENST00000376392	ENST00000394465	NME2	chr17	49245704	+	CCL4L2	chr17	34539178	+
5CDS-intron	ENST00000376392	ENST00000378342	NME2	chr17	49245704	+	CCL4L2	chr17	34539178	+
5CDS-intron	ENST00000376392	ENST00000394463	NME2	chr17	49245704	+	CCL4L2	chr17	34539178	+
5CDS-intron	ENST00000376392	ENST00000339270	NME2	chr17	49245704	+	CCL4L2	chr17	34539178	+
5CDS-intron	ENST00000376392	ENST00000482104	NME2	chr17	49245704	+	CCL4L2	chr17	34539178	+
5CDS-intron	ENST00000555572	ENST00000394465	NME2	chr17	49245704	+	CCL4L2	chr17	34539178	+
5CDS-intron	ENST00000555572	ENST00000378342	NME2	chr17	49245704	+	CCL4L2	chr17	34539178	+
5CDS-intron	ENST00000555572	ENST00000394463	NME2	chr17	49245704	+	CCL4L2	chr17	34539178	+
5CDS-intron	ENST00000555572	ENST00000339270	NME2	chr17	49245704	+	CCL4L2	chr17	34539178	+
5CDS-intron	ENST00000555572	ENST00000482104	NME2	chr17	49245704	+	CCL4L2	chr17	34539178	+

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FusionProtFeatures for NME2_CCL4L2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NME2 P22392	CCL4L2 Q8NHW4

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Fusion gene ID: 24488

FusionGeneSummary for NME2_CCL4L2

FusionProtFeatures for NME2_CCL4L2