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Fusion gene ID: 2442 |
FusionGeneSummary for ARHGAP32_TP53AIP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGAP32_TP53AIP1 | Fusion gene ID: 2442 | Hgene | Tgene | Gene symbol | ARHGAP32 | TP53AIP1 | Gene ID | 9743 | 63970 |
| Gene name | Rho GTPase activating protein 32 | tumor protein p53 regulated apoptosis inducing protein 1 | |
| Synonyms | GC-GAP|GRIT|PX-RICS|RICS|p200RhoGAP|p250GAP | P53AIP1 | |
| Cytomap | 11q24.3 | 11q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho GTPase-activating protein 32GAB-associated CDC42GAB-associated Cdc42/Rac GTPase-activating proteinGTPase regulator interacting with TrkAGTPase-activating protein for Cdc42 and Rac1RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signa | p53-regulated apoptosis-inducing protein 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | A7KAX9 | Q9HCN2 | |
| Ensembl transtripts involved in fusion gene | ENST00000310343, ENST00000524655, ENST00000392657, ENST00000527272, | ENST00000458238, ENST00000531399, ENST00000602346, ENST00000530777, | |
| Fusion gene scores | * DoF score | 9 X 7 X 4=252 | 1 X 1 X 1=1 |
| # samples | 9 | 1 | |
| ** MAII score | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ARHGAP32 [Title/Abstract] AND TP53AIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-52-7810-01A | ARHGAP32 | chr11 | 128963516 | - | TP53AIP1 | chr11 | 128806544 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000310343 | ENST00000458238 | ARHGAP32 | chr11 | 128963516 | - | TP53AIP1 | chr11 | 128806544 | - |
| In-frame | ENST00000310343 | ENST00000531399 | ARHGAP32 | chr11 | 128963516 | - | TP53AIP1 | chr11 | 128806544 | - |
| 5CDS-3UTR | ENST00000310343 | ENST00000602346 | ARHGAP32 | chr11 | 128963516 | - | TP53AIP1 | chr11 | 128806544 | - |
| 5CDS-3UTR | ENST00000310343 | ENST00000530777 | ARHGAP32 | chr11 | 128963516 | - | TP53AIP1 | chr11 | 128806544 | - |
| In-frame | ENST00000524655 | ENST00000458238 | ARHGAP32 | chr11 | 128963516 | - | TP53AIP1 | chr11 | 128806544 | - |
| In-frame | ENST00000524655 | ENST00000531399 | ARHGAP32 | chr11 | 128963516 | - | TP53AIP1 | chr11 | 128806544 | - |
| 5CDS-3UTR | ENST00000524655 | ENST00000602346 | ARHGAP32 | chr11 | 128963516 | - | TP53AIP1 | chr11 | 128806544 | - |
| 5CDS-3UTR | ENST00000524655 | ENST00000530777 | ARHGAP32 | chr11 | 128963516 | - | TP53AIP1 | chr11 | 128806544 | - |
| intron-3CDS | ENST00000392657 | ENST00000458238 | ARHGAP32 | chr11 | 128963516 | - | TP53AIP1 | chr11 | 128806544 | - |
| intron-3CDS | ENST00000392657 | ENST00000531399 | ARHGAP32 | chr11 | 128963516 | - | TP53AIP1 | chr11 | 128806544 | - |
| intron-3UTR | ENST00000392657 | ENST00000602346 | ARHGAP32 | chr11 | 128963516 | - | TP53AIP1 | chr11 | 128806544 | - |
| intron-3UTR | ENST00000392657 | ENST00000530777 | ARHGAP32 | chr11 | 128963516 | - | TP53AIP1 | chr11 | 128806544 | - |
| intron-3CDS | ENST00000527272 | ENST00000458238 | ARHGAP32 | chr11 | 128963516 | - | TP53AIP1 | chr11 | 128806544 | - |
| intron-3CDS | ENST00000527272 | ENST00000531399 | ARHGAP32 | chr11 | 128963516 | - | TP53AIP1 | chr11 | 128806544 | - |
| intron-3UTR | ENST00000527272 | ENST00000602346 | ARHGAP32 | chr11 | 128963516 | - | TP53AIP1 | chr11 | 128806544 | - |
| intron-3UTR | ENST00000527272 | ENST00000530777 | ARHGAP32 | chr11 | 128963516 | - | TP53AIP1 | chr11 | 128806544 | - |
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FusionProtFeatures for ARHGAP32_TP53AIP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARHGAP32 | TP53AIP1 |