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Fusion gene ID: 24380 |
FusionGeneSummary for NIPAL3_PPP4R1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NIPAL3_PPP4R1 | Fusion gene ID: 24380 | Hgene | Tgene | Gene symbol | NIPAL3 | PPP4R1 | Gene ID | 57185 | 9989 |
| Gene name | NIPA like domain containing 3 | protein phosphatase 4 regulatory subunit 1 | |
| Synonyms | DJ462O23.2|NPAL3 | MEG1|PP4(Rmeg)|PP4R1 | |
| Cytomap | 1p36.11 | 18p11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NIPA-like protein 3 | serine/threonine-protein phosphatase 4 regulatory subunit 1serine/threonine phosphatase 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q6P499 | Q8TF05 | |
| Ensembl transtripts involved in fusion gene | ENST00000374399, ENST00000003912, ENST00000358028, ENST00000339255, ENST00000428131, ENST00000488155, | ENST00000400556, ENST00000400555, ENST00000580583, | |
| Fusion gene scores | * DoF score | 3 X 4 X 4=48 | 8 X 7 X 5=280 |
| # samples | 4 | 8 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NIPAL3 [Title/Abstract] AND PPP4R1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-XF-AAMY-01A | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000374399 | ENST00000400556 | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
| Frame-shift | ENST00000374399 | ENST00000400555 | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
| 5CDS-intron | ENST00000374399 | ENST00000580583 | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
| In-frame | ENST00000003912 | ENST00000400556 | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
| Frame-shift | ENST00000003912 | ENST00000400555 | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
| 5CDS-intron | ENST00000003912 | ENST00000580583 | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
| intron-3CDS | ENST00000358028 | ENST00000400556 | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
| intron-3CDS | ENST00000358028 | ENST00000400555 | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
| intron-intron | ENST00000358028 | ENST00000580583 | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
| In-frame | ENST00000339255 | ENST00000400556 | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
| Frame-shift | ENST00000339255 | ENST00000400555 | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
| 5CDS-intron | ENST00000339255 | ENST00000580583 | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
| intron-3CDS | ENST00000428131 | ENST00000400556 | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
| intron-3CDS | ENST00000428131 | ENST00000400555 | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
| intron-intron | ENST00000428131 | ENST00000580583 | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
| intron-3CDS | ENST00000488155 | ENST00000400556 | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
| intron-3CDS | ENST00000488155 | ENST00000400555 | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
| intron-intron | ENST00000488155 | ENST00000580583 | NIPAL3 | chr1 | 24790610 | + | PPP4R1 | chr18 | 9547950 | - |
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FusionProtFeatures for NIPAL3_PPP4R1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NIPAL3 | PPP4R1 |