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Fusion gene ID: 24359 |
FusionGeneSummary for NINL_GINS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NINL_GINS1 | Fusion gene ID: 24359 | Hgene | Tgene | Gene symbol | NINL | GINS1 | Gene ID | 22981 | 9837 |
| Gene name | ninein like | GINS complex subunit 1 | |
| Synonyms | NLP | IMD55|PSF1 | |
| Cytomap | 20p11.21 | 20p11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ninein-like protein | DNA replication complex GINS protein PSF1GINS complex subunit 1 (Psf1 homolog)partner of sld five-1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y2I6 | Q14691 | |
| Ensembl transtripts involved in fusion gene | ENST00000278886, ENST00000422516, ENST00000464285, | ENST00000262460, ENST00000429262, ENST00000484893, | |
| Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 3 X 2 X 3=18 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NINL [Title/Abstract] AND GINS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-77-7465-01A | NINL | chr20 | 25507044 | - | GINS1 | chr20 | 25397740 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000278886 | ENST00000262460 | NINL | chr20 | 25507044 | - | GINS1 | chr20 | 25397740 | + |
| Frame-shift | ENST00000278886 | ENST00000429262 | NINL | chr20 | 25507044 | - | GINS1 | chr20 | 25397740 | + |
| 5CDS-3UTR | ENST00000278886 | ENST00000484893 | NINL | chr20 | 25507044 | - | GINS1 | chr20 | 25397740 | + |
| Frame-shift | ENST00000422516 | ENST00000262460 | NINL | chr20 | 25507044 | - | GINS1 | chr20 | 25397740 | + |
| Frame-shift | ENST00000422516 | ENST00000429262 | NINL | chr20 | 25507044 | - | GINS1 | chr20 | 25397740 | + |
| 5CDS-3UTR | ENST00000422516 | ENST00000484893 | NINL | chr20 | 25507044 | - | GINS1 | chr20 | 25397740 | + |
| intron-3CDS | ENST00000464285 | ENST00000262460 | NINL | chr20 | 25507044 | - | GINS1 | chr20 | 25397740 | + |
| intron-3CDS | ENST00000464285 | ENST00000429262 | NINL | chr20 | 25507044 | - | GINS1 | chr20 | 25397740 | + |
| intron-3UTR | ENST00000464285 | ENST00000484893 | NINL | chr20 | 25507044 | - | GINS1 | chr20 | 25397740 | + |
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FusionProtFeatures for NINL_GINS1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NINL | GINS1 |