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Fusion gene ID: 24325 |
FusionGeneSummary for NHEJ1_CNPPD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NHEJ1_CNPPD1 | Fusion gene ID: 24325 | Hgene | Tgene | Gene symbol | NHEJ1 | CNPPD1 | Gene ID | 79840 | 27013 |
| Gene name | non-homologous end joining factor 1 | cyclin Pas1/PHO80 domain containing 1 | |
| Synonyms | XLF | C2orf24|CGI-57 | |
| Cytomap | 2q35 | 2q35 | |
| Type of gene | protein-coding | protein-coding | |
| Description | non-homologous end-joining factor 1XRCC4-like factornonhomologous end-joining factor 1protein cernunnos | protein CNPPD1cyclin Pas1/PHO80 domain-containing protein 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9H9Q4 | Q9BV87 | |
| Ensembl transtripts involved in fusion gene | ENST00000409720, ENST00000356853, ENST00000483627, | ENST00000360507, ENST00000409789, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 2 X 2 X 1=4 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: NHEJ1 [Title/Abstract] AND CNPPD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NHEJ1 | GO:0010212 | response to ionizing radiation | 16439205 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE089557 | NHEJ1 | chr2 | 219940368 | - | CNPPD1 | chr2 | 220037166 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000409720 | ENST00000360507 | NHEJ1 | chr2 | 219940368 | - | CNPPD1 | chr2 | 220037166 | - |
| intron-3UTR | ENST00000409720 | ENST00000409789 | NHEJ1 | chr2 | 219940368 | - | CNPPD1 | chr2 | 220037166 | - |
| intron-3UTR | ENST00000356853 | ENST00000360507 | NHEJ1 | chr2 | 219940368 | - | CNPPD1 | chr2 | 220037166 | - |
| intron-3UTR | ENST00000356853 | ENST00000409789 | NHEJ1 | chr2 | 219940368 | - | CNPPD1 | chr2 | 220037166 | - |
| intron-3UTR | ENST00000483627 | ENST00000360507 | NHEJ1 | chr2 | 219940368 | - | CNPPD1 | chr2 | 220037166 | - |
| intron-3UTR | ENST00000483627 | ENST00000409789 | NHEJ1 | chr2 | 219940368 | - | CNPPD1 | chr2 | 220037166 | - |
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FusionProtFeatures for NHEJ1_CNPPD1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NHEJ1 | CNPPD1 |