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Fusion gene ID: 24268 |
FusionGeneSummary for NFKB1_MANBA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NFKB1_MANBA | Fusion gene ID: 24268 | Hgene | Tgene | Gene symbol | NFKB1 | MANBA | Gene ID | 4790 | 4126 |
| Gene name | nuclear factor kappa B subunit 1 | mannosidase beta | |
| Synonyms | CVID12|EBP-1|KBF1|NF-kB1|NF-kappa-B|NF-kappaB|NFKB-p105|NFKB-p50|NFkappaB|p105|p50 | MANB1 | |
| Cytomap | 4q24 | 4q24 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear factor NF-kappa-B p105 subunitDNA-binding factor KBF1NF-kappabetanuclear factor NF-kappa-B p50 subunitnuclear factor kappa-B DNA binding subunitnuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | beta-mannosidasebeta-mannosidase Alysosomal beta A mannosidasemannanasemannasemannosidase, beta A, lysosomal | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P19838 | O00462 | |
| Ensembl transtripts involved in fusion gene | ENST00000226574, ENST00000394820, ENST00000505458, ENST00000510638, ENST00000600343, | ENST00000226578, ENST00000505239, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 4 X 4 X 4=64 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NFKB1 [Title/Abstract] AND MANBA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NFKB1 | GO:0010629 | negative regulation of gene expression | 26687115 |
| Hgene | NFKB1 | GO:0010956 | negative regulation of calcidiol 1-monooxygenase activity | 15243130 |
| Hgene | NFKB1 | GO:0045893 | positive regulation of transcription, DNA-templated | 17426251 |
| Hgene | NFKB1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 1406630 |
| Hgene | NFKB1 | GO:1900127 | positive regulation of hyaluronan biosynthetic process | 17324121 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-E1-5304-01A | NFKB1 | chr4 | 103422945 | + | MANBA | chr4 | 103571858 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000226574 | ENST00000226578 | NFKB1 | chr4 | 103422945 | + | MANBA | chr4 | 103571858 | - |
| 5UTR-3CDS | ENST00000226574 | ENST00000505239 | NFKB1 | chr4 | 103422945 | + | MANBA | chr4 | 103571858 | - |
| 5UTR-3CDS | ENST00000394820 | ENST00000226578 | NFKB1 | chr4 | 103422945 | + | MANBA | chr4 | 103571858 | - |
| 5UTR-3CDS | ENST00000394820 | ENST00000505239 | NFKB1 | chr4 | 103422945 | + | MANBA | chr4 | 103571858 | - |
| intron-3CDS | ENST00000505458 | ENST00000226578 | NFKB1 | chr4 | 103422945 | + | MANBA | chr4 | 103571858 | - |
| intron-3CDS | ENST00000505458 | ENST00000505239 | NFKB1 | chr4 | 103422945 | + | MANBA | chr4 | 103571858 | - |
| intron-3CDS | ENST00000510638 | ENST00000226578 | NFKB1 | chr4 | 103422945 | + | MANBA | chr4 | 103571858 | - |
| intron-3CDS | ENST00000510638 | ENST00000505239 | NFKB1 | chr4 | 103422945 | + | MANBA | chr4 | 103571858 | - |
| intron-3CDS | ENST00000600343 | ENST00000226578 | NFKB1 | chr4 | 103422945 | + | MANBA | chr4 | 103571858 | - |
| intron-3CDS | ENST00000600343 | ENST00000505239 | NFKB1 | chr4 | 103422945 | + | MANBA | chr4 | 103571858 | - |
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FusionProtFeatures for NFKB1_MANBA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NFKB1 | MANBA |