	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 24253

FusionGeneSummary for NFIX_GCDH

Fusion gene summary

Fusion gene information	Fusion gene name: NFIX_GCDH
	Fusion gene ID: 24253
		Hgene	Tgene
	Gene symbol	NFIX	GCDH
	Gene ID	4784	2639
	Gene name	nuclear factor I X	glutaryl-CoA dehydrogenase
	Synonyms	CTF\|MRSHSS\|NF-I/X\|NF1-X\|NF1A\|SOTOS2	ACAD5\|GCD
	Cytomap	19p13.13	19p13.13
	Type of gene	protein-coding	protein-coding
	Description	nuclear factor 1 X-typeCCAAT-binding transcription factorCCAAT-box-binding transcription factorTGGCA-binding proteinnuclear factor 1/X	glutaryl-CoA dehydrogenase, mitochondrialglutaryl-Coenzyme A dehydrogenasetruncated GCDHtruncated glutaryl-CoA dehydrogenase
	Modification date	20180523	20180523
	UniProtAcc	Q14938	Q92947
	Ensembl transtripts involved in fusion gene	ENST00000397661, ENST00000592199, ENST00000587760, ENST00000585575, ENST00000360105, ENST00000588228, ENST00000587260, ENST00000358552, ENST00000588680,	ENST00000222214, ENST00000591470, ENST00000457854, ENST00000422947, ENST00000588242,
Fusion gene scores	* DoF score	21 X 12 X 14=3528	6 X 7 X 4=168
	# samples	29	7
	** MAII score	log2(29/3528*10)=-3.60472575554259 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NFIX [Title/Abstract] AND GCDH [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NFIX	GO:0000122	negative regulation of transcription by RNA polymerase II	19706729
Hgene	NFIX	GO:0045944	positive regulation of transcription by RNA polymerase II	19706729
Tgene	GCDH	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	25416781

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LUAD	TCGA-55-8506-01A	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
TCGA	RV	LUSC	TCGA-94-8491-01A	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000397661	ENST00000222214	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000397661	ENST00000591470	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000397661	ENST00000457854	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
5CDS-intron	ENST00000397661	ENST00000422947	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
5CDS-intron	ENST00000397661	ENST00000588242	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000592199	ENST00000222214	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000592199	ENST00000591470	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000592199	ENST00000457854	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
5CDS-intron	ENST00000592199	ENST00000422947	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
5CDS-intron	ENST00000592199	ENST00000588242	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000587760	ENST00000222214	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000587760	ENST00000591470	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000587760	ENST00000457854	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
5CDS-intron	ENST00000587760	ENST00000422947	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
5CDS-intron	ENST00000587760	ENST00000588242	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000585575	ENST00000222214	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000585575	ENST00000591470	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000585575	ENST00000457854	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
5CDS-intron	ENST00000585575	ENST00000422947	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
5CDS-intron	ENST00000585575	ENST00000588242	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000360105	ENST00000222214	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000360105	ENST00000591470	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000360105	ENST00000457854	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
5CDS-intron	ENST00000360105	ENST00000422947	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
5CDS-intron	ENST00000360105	ENST00000588242	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000588228	ENST00000222214	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000588228	ENST00000591470	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000588228	ENST00000457854	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
5CDS-intron	ENST00000588228	ENST00000422947	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
5CDS-intron	ENST00000588228	ENST00000588242	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000587260	ENST00000222214	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000587260	ENST00000591470	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000587260	ENST00000457854	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
5CDS-intron	ENST00000587260	ENST00000422947	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
5CDS-intron	ENST00000587260	ENST00000588242	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000358552	ENST00000222214	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000358552	ENST00000591470	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
In-frame	ENST00000358552	ENST00000457854	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
5CDS-intron	ENST00000358552	ENST00000422947	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
5CDS-intron	ENST00000358552	ENST00000588242	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
intron-3CDS	ENST00000588680	ENST00000222214	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
intron-3CDS	ENST00000588680	ENST00000591470	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
intron-3CDS	ENST00000588680	ENST00000457854	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
intron-intron	ENST00000588680	ENST00000422947	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
intron-intron	ENST00000588680	ENST00000588242	NFIX	chr19	13136366	+	GCDH	chr19	13002930	+
5CDS-5UTR	ENST00000397661	ENST00000222214	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000397661	ENST00000591470	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000397661	ENST00000457854	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000397661	ENST00000422947	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-intron	ENST00000397661	ENST00000588242	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000592199	ENST00000222214	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000592199	ENST00000591470	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000592199	ENST00000457854	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000592199	ENST00000422947	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-intron	ENST00000592199	ENST00000588242	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000587760	ENST00000222214	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000587760	ENST00000591470	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000587760	ENST00000457854	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000587760	ENST00000422947	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-intron	ENST00000587760	ENST00000588242	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000585575	ENST00000222214	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000585575	ENST00000591470	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000585575	ENST00000457854	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000585575	ENST00000422947	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-intron	ENST00000585575	ENST00000588242	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000360105	ENST00000222214	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000360105	ENST00000591470	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000360105	ENST00000457854	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000360105	ENST00000422947	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-intron	ENST00000360105	ENST00000588242	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000588228	ENST00000222214	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000588228	ENST00000591470	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000588228	ENST00000457854	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000588228	ENST00000422947	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-intron	ENST00000588228	ENST00000588242	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000587260	ENST00000222214	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000587260	ENST00000591470	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000587260	ENST00000457854	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000587260	ENST00000422947	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-intron	ENST00000587260	ENST00000588242	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000358552	ENST00000222214	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000358552	ENST00000591470	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000358552	ENST00000457854	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-5UTR	ENST00000358552	ENST00000422947	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
5CDS-intron	ENST00000358552	ENST00000588242	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
intron-5UTR	ENST00000588680	ENST00000222214	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
intron-5UTR	ENST00000588680	ENST00000591470	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
intron-5UTR	ENST00000588680	ENST00000457854	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
intron-5UTR	ENST00000588680	ENST00000422947	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+
intron-intron	ENST00000588680	ENST00000588242	NFIX	chr19	13136366	+	GCDH	chr19	13002085	+

Top

FusionProtFeatures for NFIX_GCDH

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NFIX Q14938	GCDH Q92947

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 24253

FusionGeneSummary for NFIX_GCDH

FusionProtFeatures for NFIX_GCDH