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Fusion gene ID: 24223 |
FusionGeneSummary for NFIB_KIF13B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NFIB_KIF13B | Fusion gene ID: 24223 | Hgene | Tgene | Gene symbol | NFIB | KIF13B | Gene ID | 4781 | 23303 |
| Gene name | nuclear factor I B | kinesin family member 13B | |
| Synonyms | CTF|HMGIC/NFIB|NF-I/B|NF1-B|NFI-B|NFI-RED|NFIB2|NFIB3 | GAKIN | |
| Cytomap | 9p23-p22.3 | 8p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear factor 1 B-typeCCAAT-box-binding transcription factorTGGCA-binding proteinnuclear factor 1/B | kinesin-like protein KIF13Bguanylate kinase associated kinesinkinesin 13Bkinesin-like protein GAKIN | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O00712 | Q9NQT8 | |
| Ensembl transtripts involved in fusion gene | ENST00000380934, ENST00000380959, ENST00000380953, ENST00000397575, ENST00000397581, ENST00000397579, ENST00000543693, ENST00000380924, ENST00000380921, | ENST00000524189, ENST00000521515, ENST00000404075, | |
| Fusion gene scores | * DoF score | 8 X 8 X 4=256 | 3 X 3 X 2=18 |
| # samples | 8 | 3 | |
| ** MAII score | log2(8/256*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NFIB [Title/Abstract] AND KIF13B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NFIB | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9099724|19540848 |
| Tgene | KIF13B | GO:0050770 | regulation of axonogenesis | 20194617 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DB383011 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000380934 | ENST00000524189 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-intron | ENST00000380934 | ENST00000521515 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-intron | ENST00000380934 | ENST00000404075 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-3CDS | ENST00000380959 | ENST00000524189 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-intron | ENST00000380959 | ENST00000521515 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-intron | ENST00000380959 | ENST00000404075 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-3CDS | ENST00000380953 | ENST00000524189 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-intron | ENST00000380953 | ENST00000521515 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-intron | ENST00000380953 | ENST00000404075 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-3CDS | ENST00000397575 | ENST00000524189 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-intron | ENST00000397575 | ENST00000521515 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-intron | ENST00000397575 | ENST00000404075 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-3CDS | ENST00000397581 | ENST00000524189 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-intron | ENST00000397581 | ENST00000521515 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-intron | ENST00000397581 | ENST00000404075 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-3CDS | ENST00000397579 | ENST00000524189 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-intron | ENST00000397579 | ENST00000521515 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-intron | ENST00000397579 | ENST00000404075 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-3CDS | ENST00000543693 | ENST00000524189 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-intron | ENST00000543693 | ENST00000521515 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-intron | ENST00000543693 | ENST00000404075 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-3CDS | ENST00000380924 | ENST00000524189 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-intron | ENST00000380924 | ENST00000521515 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-intron | ENST00000380924 | ENST00000404075 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-3CDS | ENST00000380921 | ENST00000524189 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-intron | ENST00000380921 | ENST00000521515 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
| intron-intron | ENST00000380921 | ENST00000404075 | NFIB | chr9 | 14082130 | + | KIF13B | chr8 | 28988123 | + |
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FusionProtFeatures for NFIB_KIF13B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NFIB | KIF13B |