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Fusion gene ID: 24202 |
FusionGeneSummary for NFE2L3_POU6F2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NFE2L3_POU6F2 | Fusion gene ID: 24202 | Hgene | Tgene | Gene symbol | NFE2L3 | POU6F2 | Gene ID | 9603 | 11281 |
| Gene name | nuclear factor, erythroid 2 like 3 | POU class 6 homeobox 2 | |
| Synonyms | NRF3 | RPF-1|WT5|WTSL | |
| Cytomap | 7p15.2 | 7p14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear factor erythroid 2-related factor 3NF-E2-related factor 3NFE2-related factor 3nuclear factor, erythroid derived 2, like 3nuclear factor-erythroid 2 p45-related factor 3 | POU domain, class 6, transcription factor 2Wilms tumor suppressor locusretina-derived POU-domain factor-1 | |
| Modification date | 20180523 | 20180403 | |
| UniProtAcc | Q9Y4A8 | P78424 | |
| Ensembl transtripts involved in fusion gene | ENST00000056233, | ENST00000403058, ENST00000518318, ENST00000517348, ENST00000559001, ENST00000464276, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 5 X 5 X 7=175 |
| # samples | 3 | 9 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/175*10)=-0.959358015502654 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NFE2L3 [Title/Abstract] AND POU6F2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-RN-AAAQ-01A | NFE2L3 | chr7 | 26217742 | + | POU6F2 | chr7 | 39379241 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000056233 | ENST00000403058 | NFE2L3 | chr7 | 26217742 | + | POU6F2 | chr7 | 39379241 | + |
| Frame-shift | ENST00000056233 | ENST00000518318 | NFE2L3 | chr7 | 26217742 | + | POU6F2 | chr7 | 39379241 | + |
| 5CDS-3UTR | ENST00000056233 | ENST00000517348 | NFE2L3 | chr7 | 26217742 | + | POU6F2 | chr7 | 39379241 | + |
| 5CDS-3UTR | ENST00000056233 | ENST00000559001 | NFE2L3 | chr7 | 26217742 | + | POU6F2 | chr7 | 39379241 | + |
| 5CDS-intron | ENST00000056233 | ENST00000464276 | NFE2L3 | chr7 | 26217742 | + | POU6F2 | chr7 | 39379241 | + |
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FusionProtFeatures for NFE2L3_POU6F2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NFE2L3 | POU6F2 |