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Fusion gene ID: 24080 |
FusionGeneSummary for NEXN_UBN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NEXN_UBN2 | Fusion gene ID: 24080 | Hgene | Tgene | Gene symbol | NEXN | UBN2 | Gene ID | 91624 | 254048 |
| Gene name | nexilin F-actin binding protein | ubinuclein 2 | |
| Synonyms | CMH20|NELIN | - | |
| Cytomap | 1p31.1 | 7q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nexilin | ubinuclein-2 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q0ZGT2 | Q6ZU65 | |
| Ensembl transtripts involved in fusion gene | ENST00000457030, ENST00000330010, ENST00000294624, ENST00000334785, ENST00000480732, | ENST00000288561, ENST00000473989, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 4 X 4 X 1=16 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NEXN [Title/Abstract] AND UBN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NEXN | GO:0030334 | regulation of cell migration | 15823560 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BX470812 | NEXN | chr1 | 78356582 | - | UBN2 | chr7 | 138989462 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000457030 | ENST00000288561 | NEXN | chr1 | 78356582 | - | UBN2 | chr7 | 138989462 | + |
| intron-3UTR | ENST00000457030 | ENST00000473989 | NEXN | chr1 | 78356582 | - | UBN2 | chr7 | 138989462 | + |
| intron-3UTR | ENST00000330010 | ENST00000288561 | NEXN | chr1 | 78356582 | - | UBN2 | chr7 | 138989462 | + |
| intron-3UTR | ENST00000330010 | ENST00000473989 | NEXN | chr1 | 78356582 | - | UBN2 | chr7 | 138989462 | + |
| intron-3UTR | ENST00000294624 | ENST00000288561 | NEXN | chr1 | 78356582 | - | UBN2 | chr7 | 138989462 | + |
| intron-3UTR | ENST00000294624 | ENST00000473989 | NEXN | chr1 | 78356582 | - | UBN2 | chr7 | 138989462 | + |
| intron-3UTR | ENST00000334785 | ENST00000288561 | NEXN | chr1 | 78356582 | - | UBN2 | chr7 | 138989462 | + |
| intron-3UTR | ENST00000334785 | ENST00000473989 | NEXN | chr1 | 78356582 | - | UBN2 | chr7 | 138989462 | + |
| intron-3UTR | ENST00000480732 | ENST00000288561 | NEXN | chr1 | 78356582 | - | UBN2 | chr7 | 138989462 | + |
| intron-3UTR | ENST00000480732 | ENST00000473989 | NEXN | chr1 | 78356582 | - | UBN2 | chr7 | 138989462 | + |
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FusionProtFeatures for NEXN_UBN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NEXN | UBN2 |