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Fusion gene ID: 24059 |
FusionGeneSummary for NET1_USP6NL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NET1_USP6NL | Fusion gene ID: 24059 | Hgene | Tgene | Gene symbol | NET1 | USP6NL | Gene ID | 55119 | 9712 |
| Gene name | pre-mRNA processing factor 38B | USP6 N-terminal like | |
| Synonyms | NET1 | RNTRE|TRE2NL|USP6NL-IT1 | |
| Cytomap | 1p13.3 | 10p14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pre-mRNA-splicing factor 38BPRP38 pre-mRNA processing factor 38 domain containing Bsarcoma antigen NY-SAR-27 | USP6 N-terminal-like proteinrelated to the N-terminus of tre | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q7Z628 | Q92738 | |
| Ensembl transtripts involved in fusion gene | ENST00000355029, ENST00000542715, ENST00000380359, ENST00000484741, | ENST00000609104, ENST00000277575, ENST00000379237, ENST00000443016, ENST00000609853, | |
| Fusion gene scores | * DoF score | 5 X 3 X 5=75 | 2 X 1 X 2=4 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: NET1 [Title/Abstract] AND USP6NL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | USP6NL | GO:0043547 | positive regulation of GTPase activity | 17562788 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-XF-A8HD-01A | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000355029 | ENST00000609104 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| Frame-shift | ENST00000355029 | ENST00000277575 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| Frame-shift | ENST00000355029 | ENST00000379237 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| 5CDS-intron | ENST00000355029 | ENST00000443016 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| 5CDS-intron | ENST00000355029 | ENST00000609853 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| 5UTR-3CDS | ENST00000542715 | ENST00000609104 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| 5UTR-3CDS | ENST00000542715 | ENST00000277575 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| 5UTR-3CDS | ENST00000542715 | ENST00000379237 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| 5UTR-intron | ENST00000542715 | ENST00000443016 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| 5UTR-intron | ENST00000542715 | ENST00000609853 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| intron-3CDS | ENST00000380359 | ENST00000609104 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| intron-3CDS | ENST00000380359 | ENST00000277575 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| intron-3CDS | ENST00000380359 | ENST00000379237 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| intron-intron | ENST00000380359 | ENST00000443016 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| intron-intron | ENST00000380359 | ENST00000609853 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| intron-3CDS | ENST00000484741 | ENST00000609104 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| intron-3CDS | ENST00000484741 | ENST00000277575 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| intron-3CDS | ENST00000484741 | ENST00000379237 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| intron-intron | ENST00000484741 | ENST00000443016 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
| intron-intron | ENST00000484741 | ENST00000609853 | NET1 | chr10 | 5471192 | + | USP6NL | chr10 | 11569566 | - |
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FusionProtFeatures for NET1_USP6NL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NET1 | USP6NL |