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Fusion gene ID: 2403 |
FusionGeneSummary for ARHGAP23_HECTD4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGAP23_HECTD4 | Fusion gene ID: 2403 | Hgene | Tgene | Gene symbol | ARHGAP23 | HECTD4 | Gene ID | 57636 | 283450 |
| Gene name | Rho GTPase activating protein 23 | HECT domain E3 ubiquitin protein ligase 4 | |
| Synonyms | - | C12ord51|C12orf51|HEEL|POTAGE | |
| Cytomap | 17q12 | 12q24.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho GTPase-activating protein 23rho-type GTPase-activating protein 23 | probable E3 ubiquitin-protein ligase HECTD4AF-1 specific protein phosphataseHECT domain containing E3 ubiquitin protein ligase 4HECT domain-containing protein 4HECT-type E3 ubiquitin transferase HECTD4probable E3 ubiquitin-protein ligase C12orf51tra | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9P227 | Q9Y4D8 | |
| Ensembl transtripts involved in fusion gene | ENST00000431231, ENST00000437668, ENST00000582409, ENST00000443378, | ENST00000377560, ENST00000430131, ENST00000550722, ENST00000549141, | |
| Fusion gene scores | * DoF score | 12 X 10 X 8=960 | 9 X 9 X 6=486 |
| # samples | 11 | 10 | |
| ** MAII score | log2(11/960*10)=-3.12553088208386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/486*10)=-2.28095631383106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ARHGAP23 [Title/Abstract] AND HECTD4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE700195 | ARHGAP23 | chr17 | 36625863 | + | HECTD4 | chr12 | 112631311 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000431231 | ENST00000377560 | ARHGAP23 | chr17 | 36625863 | + | HECTD4 | chr12 | 112631311 | - |
| Frame-shift | ENST00000431231 | ENST00000430131 | ARHGAP23 | chr17 | 36625863 | + | HECTD4 | chr12 | 112631311 | - |
| Frame-shift | ENST00000431231 | ENST00000550722 | ARHGAP23 | chr17 | 36625863 | + | HECTD4 | chr12 | 112631311 | - |
| 5CDS-intron | ENST00000431231 | ENST00000549141 | ARHGAP23 | chr17 | 36625863 | + | HECTD4 | chr12 | 112631311 | - |
| Frame-shift | ENST00000437668 | ENST00000377560 | ARHGAP23 | chr17 | 36625863 | + | HECTD4 | chr12 | 112631311 | - |
| Frame-shift | ENST00000437668 | ENST00000430131 | ARHGAP23 | chr17 | 36625863 | + | HECTD4 | chr12 | 112631311 | - |
| Frame-shift | ENST00000437668 | ENST00000550722 | ARHGAP23 | chr17 | 36625863 | + | HECTD4 | chr12 | 112631311 | - |
| 5CDS-intron | ENST00000437668 | ENST00000549141 | ARHGAP23 | chr17 | 36625863 | + | HECTD4 | chr12 | 112631311 | - |
| intron-3CDS | ENST00000582409 | ENST00000377560 | ARHGAP23 | chr17 | 36625863 | + | HECTD4 | chr12 | 112631311 | - |
| intron-3CDS | ENST00000582409 | ENST00000430131 | ARHGAP23 | chr17 | 36625863 | + | HECTD4 | chr12 | 112631311 | - |
| intron-3CDS | ENST00000582409 | ENST00000550722 | ARHGAP23 | chr17 | 36625863 | + | HECTD4 | chr12 | 112631311 | - |
| intron-intron | ENST00000582409 | ENST00000549141 | ARHGAP23 | chr17 | 36625863 | + | HECTD4 | chr12 | 112631311 | - |
| Frame-shift | ENST00000443378 | ENST00000377560 | ARHGAP23 | chr17 | 36625863 | + | HECTD4 | chr12 | 112631311 | - |
| Frame-shift | ENST00000443378 | ENST00000430131 | ARHGAP23 | chr17 | 36625863 | + | HECTD4 | chr12 | 112631311 | - |
| Frame-shift | ENST00000443378 | ENST00000550722 | ARHGAP23 | chr17 | 36625863 | + | HECTD4 | chr12 | 112631311 | - |
| 5CDS-intron | ENST00000443378 | ENST00000549141 | ARHGAP23 | chr17 | 36625863 | + | HECTD4 | chr12 | 112631311 | - |
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FusionProtFeatures for ARHGAP23_HECTD4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARHGAP23 | HECTD4 |