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Fusion gene ID: 23998 |
FusionGeneSummary for NEK10_QKI |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NEK10_QKI | Fusion gene ID: 23998 | Hgene | Tgene | Gene symbol | NEK10 | QKI | Gene ID | 152110 | 9444 |
| Gene name | NIMA related kinase 10 | QKI, KH domain containing RNA binding | |
| Synonyms | - | Hqk|QK|QK1|QK3|hqkI | |
| Cytomap | 3p24.1 | 6q26 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase Nek10NIMA (never in mitosis gene a)- related kinase 10never in mitosis A-related kinase 10nimA-related protein kinase 10 | protein quakingQKI/LOC100132735 fusionRNA binding protein HQKhomolog of mouse quaking QKI (KH domain RNA binding protein)quaking homolog, KH domain RNA binding | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q6ZWH5 | Q96PU8 | |
| Ensembl transtripts involved in fusion gene | ENST00000429845, ENST00000357467, ENST00000341435, ENST00000295720, ENST00000383771, ENST00000383770, ENST00000498182, | ENST00000275262, ENST00000392127, ENST00000453779, ENST00000361752, ENST00000361195, ENST00000424802, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 13 X 14 X 6=1092 |
| # samples | 4 | 18 | |
| ** MAII score | log2(4/4*10)=3.32192809488736 | log2(18/1092*10)=-2.60090404459018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NEK10 [Title/Abstract] AND QKI [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NEK10 | GO:0006468 | protein phosphorylation | 20956560 |
| Hgene | NEK10 | GO:0031954 | positive regulation of protein autophosphorylation | 20956560 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AF142421 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + | ||
| ChiTaRS3.1 | AF142417 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + | ||
| ChiTaRS3.1 | AF142420 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000429845 | ENST00000275262 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000429845 | ENST00000392127 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000429845 | ENST00000453779 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000429845 | ENST00000361752 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000429845 | ENST00000361195 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000429845 | ENST00000424802 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000357467 | ENST00000275262 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000357467 | ENST00000392127 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000357467 | ENST00000453779 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000357467 | ENST00000361752 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000357467 | ENST00000361195 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000357467 | ENST00000424802 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000341435 | ENST00000275262 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000341435 | ENST00000392127 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000341435 | ENST00000453779 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000341435 | ENST00000361752 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000341435 | ENST00000361195 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000341435 | ENST00000424802 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000295720 | ENST00000275262 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000295720 | ENST00000392127 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000295720 | ENST00000453779 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000295720 | ENST00000361752 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000295720 | ENST00000361195 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000295720 | ENST00000424802 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000383771 | ENST00000275262 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000383771 | ENST00000392127 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000383771 | ENST00000453779 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000383771 | ENST00000361752 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000383771 | ENST00000361195 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000383771 | ENST00000424802 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000383770 | ENST00000275262 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000383770 | ENST00000392127 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000383770 | ENST00000453779 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000383770 | ENST00000361752 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000383770 | ENST00000361195 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000383770 | ENST00000424802 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000498182 | ENST00000275262 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000498182 | ENST00000392127 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000498182 | ENST00000453779 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000498182 | ENST00000361752 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000498182 | ENST00000361195 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
| intron-3CDS | ENST00000498182 | ENST00000424802 | NEK10 | chr3 | 27258070 | - | QKI | chr6 | 163836232 | + |
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FusionProtFeatures for NEK10_QKI |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NEK10 | QKI |