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Center for Computational Systems Medicine
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FusionGeneSummary

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Fusion gene ID: 23950

FusionGeneSummary for NEDD4L_ALPK2

check button Fusion gene summary
Fusion gene informationFusion gene name: NEDD4L_ALPK2
Fusion gene ID: 23950
HgeneTgene
Gene symbol

NEDD4L

ALPK2

Gene ID

23327

115701

Gene nameneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligasealpha kinase 2
SynonymsNEDD4-2|NEDD4.2|PVNH7|RSP5|hNEDD4-2HAK
Cytomap

18q21.31

18q21.31-q21.32

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase NEDD4-likeHECT-type E3 ubiquitin transferase NED4Lubiquitin-protein ligase Rsp5alpha-protein kinase 2heart alpha-kinaseheart alpha-protein kinase
Modification date2018052320180329
UniProtAcc

Q96PU5

Q86TB3

Ensembl transtripts involved in fusion geneENST00000356462, ENST00000400345, 
ENST00000589054, ENST00000256832, 
ENST00000382850, ENST00000256830, 
ENST00000588516, ENST00000456986, 
ENST00000435432, ENST00000357895, 
ENST00000586263, ENST00000456173, 
ENST00000431212, 		ENST00000361673, 
ENST00000587399, 
Fusion gene scores* DoF score18 X 11 X 9=17821 X 2 X 1=2
# samples 202
** MAII scorelog2(20/1782*10)=-3.1554254317472
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/2*10)=3.32192809488736
Context

PubMed: NEDD4L [Title/Abstract] AND ALPK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEDD4L

GO:0003254

regulation of membrane depolarization

15217910

HgeneNEDD4L

GO:0006511

ubiquitin-dependent protein catabolic process

21463633

HgeneNEDD4L

GO:0010038

response to metal ion

11244092

HgeneNEDD4L

GO:0016567

protein ubiquitination

15217910|25631046

HgeneNEDD4L

GO:0034765

regulation of ion transmembrane transport

17289006

HgeneNEDD4L

GO:0042391

regulation of membrane potential

17289006

HgeneNEDD4L

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

21463633

HgeneNEDD4L

GO:0060306

regulation of membrane repolarization

21463633

HgeneNEDD4L

GO:0070936

protein K48-linked ubiquitination

21463633

HgeneNEDD4L

GO:1901016

regulation of potassium ion transmembrane transporter activity

17289006

HgeneNEDD4L

GO:1901017

negative regulation of potassium ion transmembrane transporter activity

21463633

HgeneNEDD4L

GO:1901380

negative regulation of potassium ion transmembrane transport

21463633

HgeneNEDD4L

GO:1902306

negative regulation of sodium ion transmembrane transport

15217910

HgeneNEDD4L

GO:1903861

positive regulation of dendrite extension

23999003

HgeneNEDD4L

GO:2000009

negative regulation of protein localization to cell surface

21463633

HgeneNEDD4L

GO:2000650

negative regulation of sodium ion transmembrane transporter activity

15217910


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-VQ-A8PD-01ANEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
TCGALDSTADTCGA-VQ-A8PX-01ANEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000356462ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
5CDS-intronENST00000356462ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
Frame-shiftENST00000400345ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
5CDS-intronENST00000400345ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
Frame-shiftENST00000589054ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
5CDS-intronENST00000589054ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
5UTR-3CDSENST00000256832ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
5UTR-intronENST00000256832ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
Frame-shiftENST00000382850ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
5CDS-intronENST00000382850ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
Frame-shiftENST00000256830ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
5CDS-intronENST00000256830ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-3CDSENST00000588516ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-intronENST00000588516ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-3CDSENST00000456986ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-intronENST00000456986ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-3CDSENST00000435432ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-intronENST00000435432ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-3CDSENST00000357895ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-intronENST00000357895ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-3CDSENST00000586263ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-intronENST00000586263ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-3CDSENST00000456173ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-intronENST00000456173ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-3CDSENST00000431212ENST00000361673NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
intron-intronENST00000431212ENST00000587399NEDD4Lchr18

55711940

+ALPK2chr18

56196470

-
In-frameENST00000356462ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000356462ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000400345ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000400345ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
intron-3CDSENST00000589054ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
intron-intronENST00000589054ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000256832ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000256832ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000382850ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000382850ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000256830ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000256830ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
intron-3CDSENST00000588516ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
intron-intronENST00000588516ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000456986ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000456986ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000435432ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000435432ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000357895ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000357895ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000586263ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000586263ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000456173ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000456173ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
In-frameENST00000431212ENST00000361673NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-
5CDS-intronENST00000431212ENST00000587399NEDD4Lchr18

56033460

+ALPK2chr18

56191294

-

Top

FusionProtFeatures for NEDD4L_ALPK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEDD4L

Q96PU5

ALPK2

Q86TB3