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Fusion gene ID: 23942 |
FusionGeneSummary for NECAP1_ETS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NECAP1_ETS1 | Fusion gene ID: 23942 | Hgene | Tgene | Gene symbol | NECAP1 | ETS1 | Gene ID | 25977 | 2113 |
| Gene name | NECAP endocytosis associated 1 | ETS proto-oncogene 1, transcription factor | |
| Synonyms | EIEE21 | ETS-1|EWSR2|c-ets-1|p54 | |
| Cytomap | 12p13.31 | 11q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | adaptin ear-binding coat-associated protein 1 | protein C-ets-1Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1v-ets avian erythroblastosis virus E2 oncogene homolog 1v-ets avian erythroblastosis virus E26 oncogene homolog 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8NC96 | P14921 | |
| Ensembl transtripts involved in fusion gene | ENST00000339754, | ENST00000392668, ENST00000525404, ENST00000345075, ENST00000535549, ENST00000526145, ENST00000531611, ENST00000319397, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: NECAP1 [Title/Abstract] AND ETS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ETS1 | GO:0030578 | PML body organization | 11909962|15247905 |
| Tgene | ETS1 | GO:0045648 | positive regulation of erythrocyte differentiation | 8620536 |
| Tgene | ETS1 | GO:0045893 | positive regulation of transcription, DNA-templated | 11909962 |
| Tgene | ETS1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15001984|15247905 |
| Tgene | ETS1 | GO:0050729 | positive regulation of inflammatory response | 21310411 |
| Tgene | ETS1 | GO:0061614 | pri-miRNA transcription by RNA polymerase II | 21711453 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA621984 | NECAP1 | chr12 | 8250151 | - | ETS1 | chr11 | 128331193 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000339754 | ENST00000392668 | NECAP1 | chr12 | 8250151 | - | ETS1 | chr11 | 128331193 | + |
| 3UTR-intron | ENST00000339754 | ENST00000525404 | NECAP1 | chr12 | 8250151 | - | ETS1 | chr11 | 128331193 | + |
| 3UTR-3UTR | ENST00000339754 | ENST00000345075 | NECAP1 | chr12 | 8250151 | - | ETS1 | chr11 | 128331193 | + |
| 3UTR-3UTR | ENST00000339754 | ENST00000535549 | NECAP1 | chr12 | 8250151 | - | ETS1 | chr11 | 128331193 | + |
| 3UTR-3UTR | ENST00000339754 | ENST00000526145 | NECAP1 | chr12 | 8250151 | - | ETS1 | chr11 | 128331193 | + |
| 3UTR-intron | ENST00000339754 | ENST00000531611 | NECAP1 | chr12 | 8250151 | - | ETS1 | chr11 | 128331193 | + |
| 3UTR-intron | ENST00000339754 | ENST00000319397 | NECAP1 | chr12 | 8250151 | - | ETS1 | chr11 | 128331193 | + |
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FusionProtFeatures for NECAP1_ETS1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NECAP1 | ETS1 |